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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A DNA binding protein specific for an origin of replication of herpes simplex virus type 1.

We have identified a protein that binds specifically to an origin of replication (oris) of the herpes simplex virus type 1 genome. The oris binding protein, detectable only in nuclear extracts of infected cells, shows the same time course of appearance as the herpesvirus-induced DNA polymerase and the DNA binding protein ICP8. The partially purified oris binding protein generates a DNase I "footprint" that spans 18- of the 90-base-pair minimal oris sequence. The oris binding protein may, therefore, be analogous to other origin-specific binding proteins that are required for the initiation of viral and chromosomal DNA replication.[1]

References

  1. A DNA binding protein specific for an origin of replication of herpes simplex virus type 1. Elias, P., O'Donnell, M.E., Mocarski, E.S., Lehman, I.R. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
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