Requirement of macrophages (monocytes) for the induction of interleukin 2 receptors on B lymphocytes.
The role of macrophages (monocytes) for the induction of interleukin 2 receptors (IL 2R) on human B lymphocytes was studied by a direct immunofluorescence method with the use of a fluoresceinated anti-IL 2R monoclonal antibody and a flow cytofluorometer. Highly purified B lymphocytes alone did not induce IL 2R on their surface by stimulation with Staphylococcus aureus Cowan I, anti-mu antibody, or pokeweed mitogen. However, the addition of monocytes successfully induced IL 2R on B lymphocytes stimulated with these mitogens in a dose-dependent manner. Interleukin 1 ( IL 1) produced by monocytes could partially replace the accessory function of monocytes. In accordance with these results, the proliferation of B lymphocytes and the differentiation to immunoglobulin-producing cells in response to IL 2 were also dependent on monocytes or IL 1. These results suggest that the accessory function of macrophages for IL 2- induced B cell activation is primarily on the induction of IL 2R on B lymphocytes.[1]References
- Requirement of macrophages (monocytes) for the induction of interleukin 2 receptors on B lymphocytes. Shirakawa, F., Tanaka, Y., Eto, S., Suzuki, H., Yamashita, U. J. Immunol. (1986) [Pubmed]
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