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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cyclohexane triones, novel membrane-active antibacterial agents.

The cyclohexane triones are a novel group of synthetic antibacterial agents that are active against gram-positive bacteria, Haemophilus influenzae, and Mycobacterium smegmatis. In general, these compounds behaved in a manner similar to that of hexachlorophene, inhibiting the transport of low-molecular-weight hydrophilic substances into bacteria. Unlike cationic detergents, such as chlorhexidine, they did not cause disruption of the bacterial cytoplasmic membrane over a short time period. The most potent antibacterial cyclohexane trione studied had a reduced ability to inhibit solute transport in comparison with certain less active analogs. Cyclohexane triones may express more than a single type of antibacterial effect.[1]


  1. Cyclohexane triones, novel membrane-active antibacterial agents. Lloyd, W.J., Broadhurst, A.V., Hall, M.J., Andrews, K.J., Barber, W.E., Wong-Kai-In, P. Antimicrob. Agents Chemother. (1988) [Pubmed]
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