The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

pHisoHex     3,4,6-trichloro-2-[(2,3,5- trichloro-6...

Synonyms: Almederm, Cotofilm, Dermadex, Distodin, Gamophen, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of pHisoHex


Psychiatry related information on pHisoHex

  • Two weeks after daily topical application of hexachlorophene, a 4-week-old female kitten developed cardiovascular collapse, corneal ulcers, trembling, lethargy, and weakness [6].

High impact information on pHisoHex


Chemical compound and disease context of pHisoHex


Biological context of pHisoHex


Anatomical context of pHisoHex


Associations of pHisoHex with other chemical compounds


Gene context of pHisoHex


Analytical, diagnostic and therapeutic context of pHisoHex

  • We describe a micromethod for measuring hexachlorophene by use of gas-liquid chromatography with a 63Ni electron capture detector [33].
  • Twenty-six patients undergoing chemotherapy for acute leukemia on a protected environment-prophylactic antibiotic program were randomly assigned to bathe with either P-300 or a 3% hexachlorophene preparation [29].
  • No significant difference was found between the two groups using only hexachlorophene when compared for differences between patient-collected and nurse-collected specimens; nevertheless, the patient-collected specimens had greater proportions of low bacterial counts than those collected by the nurses [34].
  • Seven different surgical hand-scrub agents (one triclosan compound, two hexachlorophene compounds, and four iodophors) were evaluated under in-use conditions by five persons for efficacy in degerming the hands and forearms prior to performing a total of 215 total hip arthroplasties [35].
  • Hexachlorophene preparations in infant antiseptic skin care: benefits, risks, and the future [36].


  1. Environmental causes of birth defects: the hexachlorophene issue. Janerich, D.T. JAMA (1979) [Pubmed]
  2. Toxicity of hexachlorophene. Garcia-Buñuel, L. Lancet (1982) [Pubmed]
  3. Use of 3 percent hexachlorophene baths to control patient colonization by oxacillin and aminoglycoside-resistant Staphylococcus aureus. Arroyo, J.C., Postic, B. Am. J. Med. (1982) [Pubmed]
  4. Reduced nerve blood flow in hexachlorophene neuropathy: relationship to elevated endoneurial fluid pressure. Myers, R.R., Mizisin, A.P., Powell, H.C., Lampert, P.W. J. Neuropathol. Exp. Neurol. (1982) [Pubmed]
  5. An ultrastructural and biochemical study of hexachlorophane-induced fatty liver in sheep. Reid, I.M., Hall, G.A. J. Pathol. (1975) [Pubmed]
  6. Neurotoxicosis associated with the use of hexachlorophene in a cat. Thompson, J.P., Senior, D.F., Pinson, D.M., Moriello, K.A. J. Am. Vet. Med. Assoc. (1987) [Pubmed]
  7. Nosocomial Pseudomonas aeruginosa urinary tract infections. Strand, C.L., Bryant, J.K., Morgan, J.W., Foster, J.G., McDonald, H.P., Morganstern, S.L. JAMA (1982) [Pubmed]
  8. Inhibition of the Staphylococcus aureus NADPH-dependent enoyl-acyl carrier protein reductase by triclosan and hexachlorophene. Heath, R.J., Li, J., Roland, G.E., Rock, C.O. J. Biol. Chem. (2000) [Pubmed]
  9. Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation. Park, S., Gwak, J., Cho, M., Song, T., Won, J., Kim, D.E., Shin, J.G., Oh, S. Mol. Pharmacol. (2006) [Pubmed]
  10. In vitro inhibition of Giardia lamblia and Trichomonas vaginalis growth by bithionol, dichlorophene, and hexachlorophene. Takeuchi, T., Kobayashi, S., Tanabe, M., Fujiwara, T. Antimicrob. Agents Chemother. (1985) [Pubmed]
  11. Neurotoxicity of hexachlorophene in humans. II. A clinicopathological study of 46 premature infants. Shuman, R.M., Leech, R.W., Alvord, E.C. Arch. Neurol. (1975) [Pubmed]
  12. Comparison of the effects of two lipophilic acids, hexachlorophene and decanoate, on Bacillus subtilis. Levin, B.C., Freese, E. Antimicrob. Agents Chemother. (1977) [Pubmed]
  13. Enoyl-ACP reductase (FabI) of Haemophilus influenzae: steady-state kinetic mechanism and inhibition by triclosan and hexachlorophene. Marcinkeviciene, J., Jiang, W., Kopcho, L.M., Locke, G., Luo, Y., Copeland, R.A. Arch. Biochem. Biophys. (2001) [Pubmed]
  14. Comparative activity of benzoyl peroxide and hexachlorophene. In vivo studies against propionibacterium acnes in humans. Nacht, S., Gans, E.H., McGinley, K.J., Kligman, A.M. Archives of dermatology. (1983) [Pubmed]
  15. Effectiveness of topical chlorhexidine powder as an alternative to hexachlorophane for the control of Staphylococcus aureus in neonates. Wilcox, M.H., Hall, J., Gill, A.B., Fawley, W.N., Parnell, P., Verity, P. J. Hosp. Infect. (2004) [Pubmed]
  16. An outbreak og gastroenteritis due to E. coli 0142 in a neonatal nursery. Boyer, K.M., Petersen, N.J., Farzaneh, I., Pattison, C.P., Hart, M.C., Maynard, J.E. J. Pediatr. (1975) [Pubmed]
  17. Clinical pharmacology of hexachlorophene in newborn infants. Tyrala, E.E., Hillman, L.S., Hillman, R.E., Dodson, W.E. J. Pediatr. (1977) [Pubmed]
  18. Percutaneous absorption of hexachlorophene in the rat. Nakaue, H.S., Buhler, D.R. Toxicol. Appl. Pharmacol. (1976) [Pubmed]
  19. Epidemiology of methicillin-susceptible Staphylococcus aureus in the neonatal intensive care unit. Graham, P.L., Morel, A.S., Zhou, J., Wu, F., Della-Latta, P., Rubenstein, D., Saiman, L. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (2002) [Pubmed]
  20. Brain carbonic anhydrase: activity in isolated myelin and the effect of hexachlorophene. Cammer, W., Fredman, T., Rose, A.L., Norton, W.T. J. Neurochem. (1976) [Pubmed]
  21. Hexachlorophene retinopathy in rats. Towfighi, J., Gonatas, N.K., McCree, L. Lab. Invest. (1975) [Pubmed]
  22. Hexachlorophene and the central nervous system. Toxic effects in mice and baboons. Tripier, M.F., Bérard, M., Toga, M., Martin-Bouyer, G., Le Breton, R., Garat, J. Acta Neuropathol. (1981) [Pubmed]
  23. Bactericidal activity of antiseptics against methicillin-resistant Staphylococcus aureus. Haley, C.E., Marling-Cason, M., Smith, J.W., Luby, J.P., Mackowiak, P.A. J. Clin. Microbiol. (1985) [Pubmed]
  24. Increase in cerebral fluids in rats after treatment with hexachlorophane or triethyltin. Lock, E.A. Biochem. Pharmacol. (1976) [Pubmed]
  25. Hexachlorophene-induced degeneration of adrenergic nerves: application of quantitative image analysis to Falck-Hillarp fluorescence histochemistry. Henschen, A., Olson, L. Acta Neuropathol. (1983) [Pubmed]
  26. Practical technique for adequate cleansing of endoscopes: a bacteriological study of pHisoHex and Betadine. Dunkerley, R.C., Cromer, M.D., Edmiston, C.E., Dunn, G.D. Gastrointest. Endosc. (1977) [Pubmed]
  27. Care of the newborn in perinatal units in New Brunswick. Malhotra, K.K. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. (1986) [Pubmed]
  28. Myelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in central nervous system myelin. Yamamoto, Y., Yoshikawa, H., Nagano, S., Kondoh, G., Sadahiro, S., Gotow, T., Yanagihara, T., Sakoda, S. Eur. J. Neurosci. (1999) [Pubmed]
  29. Randomized trial of a hexachlorophene preparation and P-300 bacteriostatic soaps. Bodey, G.P., Ebersole, R., Hong, H.C. J. Invest. Dermatol. (1976) [Pubmed]
  30. Myelin-associated glycoprotein localized immunocytochemically in periaxonal regions of oligodendroglia during hexachlorophene intoxication. Winchell, K.H., Sternberger, N.H., Webster, H.D. Brain Res. (1982) [Pubmed]
  31. Catalytic potential of field mouse Mus booduga brain acetylcholinesterase during repeated hexachlorophene treatment. Prasad, G.V., Rajendra, W., Indira, K. Toxicol. Lett. (1984) [Pubmed]
  32. Effects of halogenated antibacterials on the erythrocyte membrane. Miller, T.L., Gaughan, P.L., Buhler, D.R. Chem. Biol. Interact. (1978) [Pubmed]
  33. Micromethod for measuring hexachlorophene in whole blood by gas-liquid chromatography. Dodson, W.E., Tyrala, E.E., Hillman, R.E. Clin. Chem. (1977) [Pubmed]
  34. A comparison of methods for collecting clean-catch urine specimens in a clinic population of obstetric patients. Chavigny, K.H., Nunnally, D.S. Am. J. Obstet. Gynecol. (1975) [Pubmed]
  35. A microbiological in-use comparison of surgical hand-washing agents. Eitzen, H.E., Ritter, M.A., French, M.L., Gioe, T.J. The Journal of bone and joint surgery. American volume. (1979) [Pubmed]
  36. Hexachlorophene preparations in infant antiseptic skin care: benefits, risks, and the future. Plueckhahn, V.D., Ballard, B.A., Banks, J.M., Collins, R.B., Flett, P.T. Med. J. Aust. (1978) [Pubmed]
WikiGenes - Universities