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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Anti-reticulin antibodies: useful adjunct to histopathology in diagnosing celiac disease, especially in a developing country.

R-1 anti-reticulin antibodies (ARA) were present in sera of 10 of the 12 children who subsequently fulfilled the ESPGAN diagnostic criteria for celiac disease ( CD), but was not found in any children in the age-matched control groups, viz., severely malnourished (n = 20), acute gastroenteritis (n = 23), normally nourished asymptomatic (n = 38), and 42 children with protracted diarrhoea and failure to thrive due to nonceliac causes. ARA was a highly specific (100%) and sensitive (83%) assay for the early diagnosis of CD. A positive ARA assay with an initial subtotal villous atrophy was seen to always suggest CD, and these together would provide a useful basis for instituting gluten-free diets in suspected cases of CD rather than histological findings alone, which may be often present in children in the third world with protracted diarrhoea and associated severe malnutrition.[1]

References

  1. Anti-reticulin antibodies: useful adjunct to histopathology in diagnosing celiac disease, especially in a developing country. Khoshoo, V., Bhan, M.K., Unsworth, D.J., Kumar, R., Walker Smith, J.A. J. Pediatr. Gastroenterol. Nutr. (1988) [Pubmed]
 
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