Glycerol metabolism in the adult dog heartworm, Dirofilaria immitis.
1. When adult Dirofilaria immitis were incubated up to 60 min in a medium containing physiological concentrations of glycerol and glucose, the mean amount of free glycerol present did not change significantly. 2. [14C]2-glycerol disappeared from media in which 1 g heartworms were incubated at a linear rate of about 0.7 mumol/hr/g during the first hour. 3. 85-95% of the radioactivity in the Folch extract remained in the aqueous phase. 4. Phosphoglycerides and diacylglycerols accounted for better than 90% of the 14C in the lipids. 5. The rate of glycerol conversion to lactate was only about 0.02% of the rate of glucose conversion under experimental conditions. 6. The data indicate that, although dog heartworms do utilize glycerol as a substrate in glycolysis, it is probably of more importance in lipid synthesis.[1]References
- Glycerol metabolism in the adult dog heartworm, Dirofilaria immitis. Hutchison, W.F., Turner, A.C. Comp. Biochem. Physiol., B (1979) [Pubmed]
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