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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Glycerol metabolism in the adult dog heartworm, Dirofilaria immitis.

1. When adult Dirofilaria immitis were incubated up to 60 min in a medium containing physiological concentrations of glycerol and glucose, the mean amount of free glycerol present did not change significantly. 2. [14C]2-glycerol disappeared from media in which 1 g heartworms were incubated at a linear rate of about 0.7 mumol/hr/g during the first hour. 3. 85-95% of the radioactivity in the Folch extract remained in the aqueous phase. 4. Phosphoglycerides and diacylglycerols accounted for better than 90% of the 14C in the lipids. 5. The rate of glycerol conversion to lactate was only about 0.02% of the rate of glucose conversion under experimental conditions. 6. The data indicate that, although dog heartworms do utilize glycerol as a substrate in glycolysis, it is probably of more importance in lipid synthesis.[1]


  1. Glycerol metabolism in the adult dog heartworm, Dirofilaria immitis. Hutchison, W.F., Turner, A.C. Comp. Biochem. Physiol., B (1979) [Pubmed]
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