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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Type-restricted neutralization of molecular clones of human immunodeficiency virus.

In a study of the immunologic significance of the genetic diversity present within single isolates of human immunodeficiency virus type 1 (HIV-1), the neutralization of viruses derived from molecular clones of the HIV-1 strain HTLV-IIIB by an extensive panel of sera was compared. Sera from HIV-1-infected patients and from goats immunized with polyacrylamide gel-purified HIV-1 envelope glycoprotein (gp120), native gp120, or gp120-derived recombinant peptides, showed marked heterogeneity in neutralizing activity against these closely related viruses. The change of a single amino acid residue in gp120 may account for such "clonal restriction" of neutralizing activity.[1]

References

  1. Type-restricted neutralization of molecular clones of human immunodeficiency virus. Looney, D.J., Fisher, A.G., Putney, S.D., Rusche, J.R., Redfield, R.R., Burke, D.S., Gallo, R.C., Wong-Staal, F. Science (1988) [Pubmed]
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