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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Translocation of epidermal growth factor to the hepatocyte nucleus during rat liver regeneration.

To determine the fate of exogenous epidermal growth factor ( EGF) in regenerating liver, 125I-labeled EGF was injected into rat portal veins at various times after 70% hepatectomy. Epidermal growth factor was taken up by the liver remnant at all time points studied (0, 4, 8, 16, and 36 h), but at 8 h after hepatectomy a large quantity was retained by the liver and EGF degradation products appearing in the bile decreased markedly. Electron microscopic autoradiography of the regenerating livers 1 h after injection of 125I- EGF demonstrated that 27% of the grains were associated with hepatocyte nuclei compared to 0.5% in shamoperated controls. There was also a concomitant decrease in grains associated with the lysosomal compartment. Nuclei isolated from regenerating livers exposed to 125I- EGF also demonstrated a three-fold increase in radioactivity compared to nuclei from control livers. Nearly 70% of nuclear radioactivity was precipitable with a specific antibody to EGF, and a small fraction appeared to be part of a high molecular weight complex. These data support the hypothesis that during the pre-S phase of liver regeneration, EGF is translocated to the nucleus rather than to lysosomes, and may participate in the initiation of deoxyribonucleic acid synthesis or alteration of gene expression.[1]


  1. Translocation of epidermal growth factor to the hepatocyte nucleus during rat liver regeneration. Raper, S.E., Burwen, S.J., Barker, M.E., Jones, A.L. Gastroenterology (1987) [Pubmed]
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