The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Activity of difloxacin (A-56619) and A-56620 against clinical anaerobic bacteria in vitro.

We determined the MICs of difloxacin (A-56619) and A-56620 against anaerobic bacteria and assessed the effects of alterations in pH, size of inoculum, addition of human serum, and repeated exposure to subinhibitory levels of antibiotics. We tested for synergism of these drugs with cefoxitin against Bacteroides spp. We found that difloxacin and A-56620 were as active as ciprofloxacin, inhibiting about 90% of B. fragilis (4 micrograms/ml) and other Bacteroides spp. (8 micrograms/ml), A-56620 being more active than difloxacin against several isolates. Increased inoculum size and changes in pH did not alter their MICs much, but human serum and exposure to sub-MICs of antibiotic effected increases in their MICs against Bacteroides spp. Cefoxitin was not synergistic with either difloxacin or A-56620 against B. fragilis.[1]

References

  1. Activity of difloxacin (A-56619) and A-56620 against clinical anaerobic bacteria in vitro. Bansal, M.B., Thadepalli, H. Antimicrob. Agents Chemother. (1987) [Pubmed]
 
WikiGenes - Universities