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Chemical Compound Review

Difloxacin     6-fluoro-1-(4-fluorophenyl)- 7-(4...

Synonyms: CHEMBL6259, SureCN148765, AC-12060, BBL010805, CTK3I6884, ...
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Disease relevance of A 56619


High impact information on A 56619


Chemical compound and disease context of A 56619


Biological context of A 56619


Anatomical context of A 56619


Associations of A 56619 with other chemical compounds


Gene context of A 56619


Analytical, diagnostic and therapeutic context of A 56619


  1. Evaluation of difloxacin in the treatment of uncomplicated urethral gonorrhea in men. Smith, B.L., Cummings, M., Benes, S., Draft, K., McCormack, W.M. Antimicrob. Agents Chemother. (1989) [Pubmed]
  2. In vitro activity of A-56619 (difloxacin), A-56620, and other new quinolone antimicrobial agents against genital pathogens. Liebowitz, L.D., Saunders, J., Fehler, G., Ballard, R.C., Koornhof, H.J. Antimicrob. Agents Chemother. (1986) [Pubmed]
  3. Comparative evaluation of A-56619, A-56620, and nafcillin in the treatment of experimental Staphylococcus aureus osteomyelitis. Mader, J.T., Morrison, L.T., Adams, K.R. Antimicrob. Agents Chemother. (1987) [Pubmed]
  4. Comparison of difloxacin, enoxacin, and cefazolin for the treatment of experimental Staphylococcus aureus endocarditis. Boscia, J.A., Kobasa, W.D., Kaye, D. Antimicrob. Agents Chemother. (1988) [Pubmed]
  5. In vitro evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones. Stamm, J.M., Hanson, C.W., Chu, D.T., Bailer, R., Vojtko, C., Fernandes, P.B. Antimicrob. Agents Chemother. (1986) [Pubmed]
  6. In vitro and in vivo activities of clarithromycin against Mycobacterium avium. Fernandes, P.B., Hardy, D.J., McDaniel, D., Hanson, C.W., Swanson, R.N. Antimicrob. Agents Chemother. (1989) [Pubmed]
  7. Antibiotic susceptibilities of two Coxiella burnetii isolates implicated in distinct clinical syndromes. Yeaman, M.R., Roman, M.J., Baca, O.G. Antimicrob. Agents Chemother. (1989) [Pubmed]
  8. In vitro evaluation of S-25930 and S-25932, two new quinolones, against aerobic gram-negative isolates from cancer patients. Rolston, K.V., Ho, D.H., LeBlanc, B., Bodey, G.P. Antimicrob. Agents Chemother. (1987) [Pubmed]
  9. Comparative antibacterial activities of temafloxacin hydrochloride (A-62254) and two reference fluoroquinolones. Hardy, D.J., Swanson, R.N., Hensey, D.M., Ramer, N.R., Bower, R.R., Hanson, C.W., Chu, D.T., Fernandes, P.B. Antimicrob. Agents Chemother. (1987) [Pubmed]
  10. Factors influencing the in vitro activity of two new aryl-fluoroquinolone antimicrobial agents, difloxacin (A-56619) and A-56620. Hirschhorn, L., Neu, H.C. Antimicrob. Agents Chemother. (1986) [Pubmed]
  11. In vitro activities of lomefloxacin and temafloxacin against pathogens causing diarrhea. Segreti, J., Nelson, J.A., Goodman, L.J., Kaplan, R.L., Trenholme, G.M. Antimicrob. Agents Chemother. (1989) [Pubmed]
  12. Induction of the SOS response by new 4-quinolones. Phillips, I., Culebras, E., Moreno, F., Baquero, F. J. Antimicrob. Chemother. (1987) [Pubmed]
  13. The comparative in-vitro activity of eight newer quinolones and nalidixic acid. King, A., Phillips, I. J. Antimicrob. Chemother. (1986) [Pubmed]
  14. Efficacy of difloxacin in calves experimentally infected with Mannheimia haemolytica. Olchowy, T.W., TerHune, T.N., Herrick, R.L. Am. J. Vet. Res. (2000) [Pubmed]
  15. Determination of the inhibitory concentration 50% (IC50) of four selected drugs (chlortetracycline, doxycycline, enrofloxacin and difloxacin) that reduce in vitro the multiplication of Chlamydophila psittaci. Failing, K., Theis, P., Kaleta, E.F. DTW. Dtsch. Tierarztl. Wochenschr. (2006) [Pubmed]
  16. Difloxacin metabolism and pharmacokinetics in humans after single oral doses. Granneman, G.R., Snyder, K.M., Shu, V.S. Antimicrob. Agents Chemother. (1986) [Pubmed]
  17. Pharmacokinetic properties and oral bioavailabilities of difloxacin in pig and chicken. Inui, T., Taira, T., Matsushita, T., Endo, T. Xenobiotica (1998) [Pubmed]
  18. Reversal of multidrug resistance-associated protein-mediated drug resistance in cultured human neuroblastoma cells by the quinolone antibiotic difloxacin. Norris, M.D., Madafiglio, J., Gilbert, J., Marshall, G.M., Haber, M. Med. Pediatr. Oncol. (2001) [Pubmed]
  19. Pharmacokinetics and milk penetration of difloxacin after intravenous, subcutaneous and intramuscular administration to lactating goats. Mar??n, P., Escudero, E., Fern??ndez-Var??n, E., C??rceles, C.M. J. Vet. Pharmacol. Ther. (2007) [Pubmed]
  20. Pharmacokinetics of difloxacin in goats. Atef, M., el-Banna, H.A., Abd el-Aty, A.M., Goudah, A. DTW. Dtsch. Tierarztl. Wochenschr. (2002) [Pubmed]
  21. Morphologic and biochemical changes in articular cartilages of immature beagle dogs dosed with difloxacin. Burkhardt, J.E., Hill, M.A., Carlton, W.W. Toxicologic pathology. (1992) [Pubmed]
  22. Immunohistochemistry of articular cartilage from immature beagle dogs dosed with difloxacin. Burkhardt, J.E., Förster, C., Lozo, E., Hill, M.A., Stahlmann, R. Toxicologic pathology. (1997) [Pubmed]
  23. Difloxacin reverses multidrug resistance in HL-60/AR cells that overexpress the multidrug resistance-related protein (MRP) gene. Gollapudi, S., Thadepalli, F., Kim, C.H., Gupta, S. Oncol. Res. (1995) [Pubmed]
  24. Pharmacokinetics of difloxacin and its concentration in body fluids and endometrial tissues of mares after repeated intragastric administration. Adams, A.R., Haines, G.R., Brown, M.P., Gronwall, R., Merritt, K. Can. J. Vet. Res. (2005) [Pubmed]
  25. Determination of quinolones in animal tissues and eggs by high-performance liquid chromatography with photodiode-array detection. Gigosos, P.G., Revesado, P.R., Cadahía, O., Fente, C.A., Vazquez, B.I., Franco, C.M., Cepeda, A. Journal of chromatography. A. (2000) [Pubmed]
  26. Determination of ciprofloxacin levels in chinchilla middle ear effusion and plasma by high-performance liquid chromatography with fluorescence detection. Lovdahl, M., Steury, J., Russlie, H., Canafax, D.M. J. Chromatogr. (1993) [Pubmed]
  27. Synergistic interactions of ciprofloxacin and extended spectrum beta-lactams or aminoglycosides against Acinetobacter calcoaceticus ss. anitratus. Chow, A.W., Wong, J., Bartlett, K.H. Diagn. Microbiol. Infect. Dis. (1988) [Pubmed]
  28. An in vitro investigation of the intraphagocytic bioactivity of difloxacin, ciprofloxacin, pefloxacin and fleroxacin. van Rensburg, C.E., Joone, G., Anderson, R. Chemotherapy. (1989) [Pubmed]
  29. Measurement of ciprofloxacin in human plasma, whole blood, and erythrocytes by high-performance liquid chromatography. Teja-Isavadharm, P., Keeratithakul, D., Watt, G., Webster, H.K., Edstein, M.D. Therapeutic drug monitoring. (1991) [Pubmed]
  30. Pharmacokinetics of difloxacin after intravenous, intramuscular, and intragastric administration to horses. Fernández-Varón, E., Cárceles, C.M., Marín, P., Martos, N., Escudero, E., Ayala, I. Am. J. Vet. Res. (2006) [Pubmed]
  31. Comparison of fluoroquinolone pharmacokinetic parameters after treatment with marbofloxacin, enrofloxacin, and difloxacin in dogs. Frazier, D.L., Thompson, L., Trettien, A., Evans, E.I. J. Vet. Pharmacol. Ther. (2000) [Pubmed]
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