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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Conversion of leukotriene C4 to leukotriene D4 by a cell-surface enzyme of rat macrophages.

Leukotriene (LT) C4-metabolizing enzyme was studied using rat leukocytes. Neutrophils and lymphocytes hardly metabolized LTC4, whereas macrophages rapidly converted LTC4 to LTD4. The LTC4-metabolizing enzyme of macrophages was present in the membrane fraction but not in the nuclear, granular and cytosol fractions. When macrophages were modified chemically with diazotized sulfanilic acid, a poorly permeant reagent which inactivates cell-surface enzymes selectively, the LTC4-metabolizing activity of macrophages decreased significantly (greater than 90%). These findings suggest that rat macrophages possess the LTC4-metabolizing enzyme which converts LTC4 to LTD4, on the cell surface membrane.[1]


  1. Conversion of leukotriene C4 to leukotriene D4 by a cell-surface enzyme of rat macrophages. Nagaoka, I., Yamashita, T. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
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