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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A regional difference in endothelium-dependent relaxation responses to acetylcholine in the canine venous system.

Endothelium-dependent relaxations of canine veins isolated from 15 different sites were examined. Acetylcholine (ACh, 10(-10)-10(-6) M) caused marked endothelium-dependent relaxations in the external jugular vein, superior vena cava, brachiocephalic vein, segment A (supradiaphragmatic portion) and D (infrarenal portion) of the inferior vena cava. However, only contractile responses were induced by ACh in the portal, mesenteric veins and the segment C of the inferior vena cava (between liver and renal veins) with or without endothelium. The other 7 veins showed only small endothelium-dependent relaxations (10-20%). These results indicated that the endothelium-dependent responses of canine veins to ACh are regionally different.[1]


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