Chromogranin C: a third component of the acidic proteins in chromaffin granules.
We characterized a group of acidic proteins of bovine chromaffin granules with an antiserum raised against a protein described by Rosa and Zanini [Eur. J. Cell Biol. 31, 94-98 (1983)] in pituitary gland. In adrenal medulla the proteins reacting with this antiserum are confined to chromaffin granules. Their largest component has a Mr of 86,000 and a pI of 5. 0. In addition six proteins of lower molecular weight are recognized by this antiserum. In a cell-free system only one protein is synthesized that can be precipitated with this antiserum. The properties of these proteins are very similar to those of the previously described chromogranins A and B; however, there is no immunological cross-reaction between these protein groups. We suggest this third group of acidic proteins of chromaffin granules be named chromogranins C.[1]References
- Chromogranin C: a third component of the acidic proteins in chromaffin granules. Fischer-Colbrie, R., Hagn, C., Kilpatrick, L., Winkler, H. J. Neurochem. (1986) [Pubmed]
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