The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Effect of electroconvulsive shock (ECS) treatment on the histaminergic system in rat brain: biochemical and behavioural studies.

The effects of electroconvulsive shock (ECS) on brain histamine (HI) levels, 1-histidine decarboxylase ( HD) and HI-methyltransferase ( HMT) activities, and H2-receptor--mediated hypothermia were studied in rats. Single (x1) and repeated (x10, once daily) ECS had practically no effect on both HI levels and HMT activities in the rat hypothalamus, cerebral cortex and rest of the brain. ECS x10 significantly increased HI accumulation. ECS x1 (only after 24 h) and ECS x10 resulted in marked elevation of the brain HD activity; the most pronounced effect was observed in the cerebral cortex. Repeated, but not single, ECS reduced the hypothermic action of various centrally given histamine H2-receptor agonists (HI, 4-methylHI, dimaprit and impromidine). It is suggested that prolonged treatment with ECS activates the central histaminergic system in the rat. The histaminergic neurons in the cerebral cortex seem to be especially affected by repeated ECS.[1]

References

 
WikiGenes - Universities