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Gene Review

Hdc  -  histidine decarboxylase

Rattus norvegicus

Synonyms: HDC, Histidine decarboxylase
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Disease relevance of Hdc

  • We describe here the first spectroscopic characterization of a mammalian histidine decarboxylase, i.e. a recombinant version of the rat enzyme purified from transformed Escherichia coli cultures, with similar kinetic constants to those reported for mammalian histidine decarboxylases purified from native sources [1].
  • Pretreatment of rats with glucocorticoid analog, dexamethasone (DMX), 1 mg/kg of body weight, given twice, 20 and 2 h before decapitation, did not influence significantly the effects invoked by peroxidation on HA levels and the activity of HD and HMT, but impaired histidine transport [2].
  • Forty-eight hours of dehydration increased the mRNA level of HDC in the tuberomammillary nuclei, whereas 24 h of dehydration had no effect [3].
  • The HDC activity per g tissue was not correlated to body weight in the control fetuses [4].
  • The prompt reduction of the mucosal histidine decarboxylase activity in response to ischemia probably reflects ECL cell damage [5].

Psychiatry related information on Hdc


High impact information on Hdc


Chemical compound and disease context of Hdc


Biological context of Hdc

  • Amino acid sequences important for the production of a 55-kDa HDC isoform were identified by successive truncations through amino acids 502, 503, and 504 [17].
  • The two domains were joined at splice junctions of the ABP-SHBG and HDC genes, which were localized to rat chromosomes 10 and 3, respectively [18].
  • Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability [19].
  • We suggest that HDC activation reflects enhanced transcription, translation and/or posttranslational enzyme activation as well as stabilization, and that a high cytosolic histamine concentration suppresses HDC activation [20].
  • This includes residues that were proposed to mediate events within the active site, and HDC proteins carrying mutations in these residues were inactive when expressed in reticulocyte cell lysates reactions [21].

Anatomical context of Hdc


Associations of Hdc with chemical compounds


Co-localisations of Hdc


Regulatory relationships of Hdc


Other interactions of Hdc


Analytical, diagnostic and therapeutic context of Hdc


  1. Spectroscopic analysis of recombinant rat histidine decarboxylase. Olmo, M.T., Sánchez-Jiménez, F., Medina, M.A., Hayashi, H. J. Biochem. (2002) [Pubmed]
  2. Peroxidation-induced changes of histamine metabolism and transport of its precursor histidine in rat brain synaptosomes. Rafałowska, U., Wałajtys-Rode, E. Free Radic. Biol. Med. (1991) [Pubmed]
  3. Dehydration stimulates hypothalamic gene expression of histamine synthesis enzyme: importance for neuroendocrine regulation of vasopressin and oxytocin secretion. Kjaer, A., Larsen, P.J., Knigge, U., Warberg, J. Endocrinology (1995) [Pubmed]
  4. Histidine decarboxylase activity in fetal intrauterine growth-retarded rats. Kwong, M.S., Moore, T.C., Lemmi, C.A., Oh, W., Thibeault, D.W. Pediatr. Res. (1976) [Pubmed]
  5. Ischemia of rat stomach mobilizes ECL cell histamine. Kitano, M., Bernsand, M., Kishimoto, Y., Norlén, P., Håkanson, R., Haenuki, Y., Kudo, M., Hasegawa, J. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  6. Effect of the histamine H3-antagonist clobenpropit on spatial memory deficits induced by MK-801 as evaluated by radial maze in Sprague-Dawley rats. Huang, Y.W., Hu, W.W., Chen, Z., Zhang, L.S., Shen, H.Q., Timmerman, H., Leurs, R., Yanai, K. Behav. Brain Res. (2004) [Pubmed]
  7. Abnormalities in obese Zuckers: defective control of histaminergic functions. Yoshimatsu, H., Machidori, H., Doi, T., Kurokawa, M., Ookuma, K., Kang, M., Fujimoto, K., Sakata, T. Physiol. Behav. (1993) [Pubmed]
  8. Effect of electroconvulsive shock (ECS) treatment on the histaminergic system in rat brain: biochemical and behavioural studies. Zawilska, J., Nowak, J.Z. Agents Actions (1986) [Pubmed]
  9. Differential control of somatostatin messenger RNA in rat gastric corpus and antrum. Role of acid, food, and capsaicin-sensitive afferent neurons. Sandvik, A.K., Dimaline, R., Forster, E.R., Evans, D., Dockray, G.J. J. Clin. Invest. (1993) [Pubmed]
  10. Histamine and histidine decarboxylase are correlated with mucosal repair in rat small intestine after ischemia-reperfusion. Fujimoto, K., Imamura, I., Granger, D.N., Wada, H., Sakata, T., Tso, P. J. Clin. Invest. (1992) [Pubmed]
  11. Regulated expression of GATA-6 transcription factor in gastric endocrine cells. Dimaline, R., Campbell, B.J., Watson, F., Sandvik, A.K., Struthers, J., Noble, P.J. Gastroenterology (1997) [Pubmed]
  12. Cholecystokinin-B receptor ligands of the dipeptoid series act as agonists on rat stomach histidine decarboxylase. Ding, X.Q., Chen, D., Håkanson, R. Gastroenterology (1995) [Pubmed]
  13. Immunohistochemical localization of 5-hydroxytryptamine, histamine and histidine decarboxylase in the rat major pelvic and coeliac-superior mesenteric ganglion. Karhula, T., Panula, P., Steinbusch, H., Häppölä, O. J. Auton. Nerv. Syst. (1990) [Pubmed]
  14. Does brain histamine contribute to the development of hypertension in spontaneously hypertensive rats? Prast, H., Philippu, A. Naunyn Schmiedebergs Arch. Pharmacol. (1991) [Pubmed]
  15. Intraduodenal instillation of acid and hyperosmolal solution suppresses pentagastrin-stimulated acid secretion but not histamine mobilization in the rat stomach. Emås, S., Håkanson, R. Scand. J. Gastroenterol. (1987) [Pubmed]
  16. Effects of dexamethasone on the activity of histidine decarboxylase, ornithine decarboxylase, and dopa decarboxylase in rat oxyntic mucosa. Araki, M., Nakamura, M., Takenoshita, S., Shoda, H., Nagamachi, Y., Matsuzaki, S. Can. J. Physiol. Pharmacol. (1991) [Pubmed]
  17. The production of 53-55-kDa isoforms is not required for rat L-histidine decarboxylase activity. Fleming, J.V., Wang, T.C. J. Biol. Chem. (2003) [Pubmed]
  18. Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by trans splicing. Sullivan, P.M., Petrusz, P., Szpirer, C., Joseph, D.R. J. Biol. Chem. (1991) [Pubmed]
  19. Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability. Rodríguez-Caso, C., Rodríguez-Agudo, D., Moya-García, A.A., Fajardo, I., Medina, M.A., Subramaniam, V., Sánchez-Jiménez, F. Eur. J. Biochem. (2003) [Pubmed]
  20. Rat stomach ECL cells: mode of activation of histidine decarboxylase. Zhao, C.M., Chen, D., Yamada, H., Dornonville de la Cour, C., Lindström, E., Persson, L., Håkanson, R. Regul. Pept. (2003) [Pubmed]
  21. Mapping of catalytically important residues in the rat L-histidine decarboxylase enzyme using bioinformatic and site-directed mutagenesis approaches. Fleming, J.V., Sánchez-Jiménez, F., Moya-García, A.A., Langlois, M.R., Wang, T.C. Biochem. J. (2004) [Pubmed]
  22. Detection of histidine decarboxylase in rat aorta and cultured rat aortic smooth muscle cells. Tippens, A.S., Davis, S.V., Hayes, J.R., Bryda, E.C., Green, T.L., Gruetter, C.A. Inflamm. Res. (2004) [Pubmed]
  23. Intracellular localization of the 74- and 53-kDa forms of L-histidine decarboxylase in a rat basophilic/mast cell line, RBL-2H3. Tanaka, S., Nemoto, K., Yamamura, E., Ichikawa, A. J. Biol. Chem. (1998) [Pubmed]
  24. Insulin receptor-related receptor messenger ribonucleic acid in the stomach is focally expressed in the enterochromaffin-like cells. Tsujimoto, K., Tsuji, N., Ozaki, K., Ohta, M., Itoh, N. Endocrinology (1995) [Pubmed]
  25. Somatostatin inhibits gastrin-induced histamine secretion and synthesis in the rat. Kondo, S., Shinomura, Y., Kanayama, S., Kawabata, S., Miyazaki, Y., Imamura, I., Fukui, H., Matsuzawa, Y. Regul. Pept. (1993) [Pubmed]
  26. Effect of cholecystokinin receptor antagonists, MK-329 and L-365,260, on cholecystokinin-induced acid secretion and histidine decarboxylase activity in the rat. Kawabata, S., Kanayama, S., Shinomura, Y., Miyazaki, Y., Imamura, I., Moriwaki, K., Wada, H., Tarui, S. Regul. Pept. (1991) [Pubmed]
  27. Newly synthesized histamine accelerates ornithine decarboxylase activity in rat intestinal mucosa after ischemia-reperfusion. Fujimoto, K., Sakata, Y., Tsunada, S., Koyama, T., Morita, H., Ogata, S., Matsunaga, C., Gotoh, Y., Iwakiri, R. Dig. Dis. Sci. (1995) [Pubmed]
  28. Interleukin-1 beta inhibits gastric histamine secretion and synthesis in the rat. Kondo, S., Shinomura, Y., Kanayama, S., Kawabata, S., Miyazaki, Y., Imamura, I., Fukui, H., Matsuzawa, Y. Am. J. Physiol. (1994) [Pubmed]
  29. Dichlorvos intoxication and gastric secretion. Maśliński, S., Ciurzyńska, G., Maślińska, D. Acta physiologica Polonica. (1979) [Pubmed]
  30. Mediation of the stress-induced prolactin release by hypothalamic histaminergic neurons and the possible involvement of vasopressin in this response. Kjaer, A., Knigge, U., Olsen, L., Vilhardt, H., Warberg, J. Endocrinology (1991) [Pubmed]
  31. Impact of Rantes and MCP-1 chemokines on in vivo basophilic cell recruitment in rat skin injection model and their role in modifying the protein and mRNA levels for histidine decarboxylase. Conti, P., Pang, X., Boucher, W., Letourneau, R., Reale, M., Barbacane, R.C., Thibault, J., Theoharides, T.C. Blood (1997) [Pubmed]
  32. Immunocytochemical localization of monoamine oxidase type B in enterochromaffin-like cells of rat oxyntic mucosa. Okauchi, H., Nakajima, S., Tani, T., Ito, A., Arai, R. Histochem. Cell Biol. (2004) [Pubmed]
  33. Ornithine decarboxylase in rat small intestine: stimulation with food or insulin. Maudsley, D.V., Leif, J., Kobayashi, Y. Am. J. Physiol. (1976) [Pubmed]
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