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Chemical Compound Review

IMPROMIDINE     2-[3-(3H-imidazol-4- yl)propyl]-1-[2-[(5...

Synonyms: Impromidina, Impromidinum, CHEMBL12608, SureCN407158, SureCN1736531, ...
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Disease relevance of IMPROMIDINE


Psychiatry related information on IMPROMIDINE

  • In normal subjects and in DU2, the administration of the lowest dose of impromidine induced a motor pattern similar to that of the basal period of groups DU and GD, whereas the highest dose disrupted the MMC pattern that was replaced by an irregular motor activity [6].

High impact information on IMPROMIDINE


Chemical compound and disease context of IMPROMIDINE

  • The gastric secretory response to impromidine (SKF 92676), a potent selective histamine H2 agonist, has been studied in 40 patients with peptic ulcer disease or ulcer-like dyspepsia [12].
  • Left ventricular infarction (AMI) was produced in experimental animals and the contractile response to beta-adrenergic and H2-histaminergic stimulation by isoproterenol and impromidine tested in the isolated perfused heart preparation [13].

Biological context of IMPROMIDINE


Anatomical context of IMPROMIDINE


Associations of IMPROMIDINE with other chemical compounds


Gene context of IMPROMIDINE


Analytical, diagnostic and therapeutic context of IMPROMIDINE


  1. Alteration of H2 receptor sensitivity in duodenal ulcer patients after maintenance treatment with an H2 receptor antagonist. Jones, D.B., Howden, C.W., Burget, D.W., Silletti, C., Hunt, R.H. Gut (1988) [Pubmed]
  2. Histamine H-2 receptor stimulation and inhibition of pepsin secretion in the dog. Hirschowitz, B.I., Rentz, J., Molina, E. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
  3. Analysis of histamine receptors in the central thermoregulatory mechanism of Mastomys natalensis. Dhawan, B.N., Shukla, R., Srimal, R.C. Br. J. Pharmacol. (1982) [Pubmed]
  4. Cardiovascular studies with impromidine (SK&F 92676), a new very potent and specific histamine H2-receptor agonist. Owen, D.A., Harvey, C.A., Gristwood, R.W. J. Pharm. Pharmacol. (1979) [Pubmed]
  5. Effective stimulation of cardiac contractility and myocardial metabolism by impromidine and dimaprit--two new H2-agonistic compounds--in the surviving, catecholamine-insensitive myocardium after coronary occlusion. Baumann, G., Felix, S.B., Riess, G., Loher, U., Ludwig, L., Blömer, H. J. Cardiovasc. Pharmacol. (1982) [Pubmed]
  6. Interdigestive gastroduodenal motility in duodenal ulcer: role of gastric acid hypersecretion. Bortolotti, M. Am. J. Gastroenterol. (1989) [Pubmed]
  7. Ontogeny of gastric acid secretion in the rat: evidence for multiple response systems. Ackerman, S.H. Science (1982) [Pubmed]
  8. Gastric secretory studies in humans with impromidine (SK&F 92676)--a specific histamine H2 receptor agonist. Hunt, R.H., Mills, J.G., Beresford, J., Billings, J.A., Burland, W.L., Milton-Thompson, G.J. Gastroenterology (1980) [Pubmed]
  9. Gastric mucosal blood flow and acid secretory changes in man with impromidine: a new specific histamine-H2-receptor agonist. McIsaac, R.L., Johnston, B.J., Fielding, L.P. Gut (1981) [Pubmed]
  10. Histamine H1 receptor activation blocks two classes of potassium current, IK(rest) and IAHP, to excite ferret vagal afferents. Jafri, M.S., Moore, K.A., Taylor, G.E., Weinreich, D. J. Physiol. (Lond.) (1997) [Pubmed]
  11. Novel effects of histamine on lipoprotein metabolism: suppression of hepatic low density lipoprotein receptor expression and reduction of plasma high density lipoprotein cholesterol in the rat. Liao, W., Rudling, M., Angelin, B. Endocrinology (1997) [Pubmed]
  12. Clinical experience with impromidine, a highly specific H2-receptor agonist. Bangerter, U., Schlup, M., Liechti, M., Häcki, W.H., Halter, F. Digestion (1981) [Pubmed]
  13. Apparent superiority of H2-receptor stimulation and simultaneous beta-blockade over conventional treatment with beta-sympathomimetic drugs in post-acute myocardial infarction: cardiac effects of impromidine--a new specific H2-receptor agonist-in the surviving catecholamine-insensitive myocardium. Baumann, G., Felix, S.B., Heidecke, C.D., Riess, G., Loher, U., Ludwig, L., Blömer, H. Agents Actions (1984) [Pubmed]
  14. Studies on the desensitization of the central cardiovascular responses of histamine. Poulakos, J.J., Gertner, S.B. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  15. Presynaptic and postsynaptic effects of histamine and histamine agonists in the superior cervical ganglion of the rat. Snow, R.W., Weinreich, D. Neuropharmacology (1987) [Pubmed]
  16. Haemodynamic studies with impromidine in anaesthetised cats and rats. Owen, D.A., Pipkin, M.A. J. Cardiovasc. Pharmacol. (1983) [Pubmed]
  17. Impromidine is a partial histamine H2-receptor agonist on human ventricular myocardium. English, T.A., Gristwood, R.W., Owen, D.A., Wallwork, J. Br. J. Pharmacol. (1986) [Pubmed]
  18. Comparison of the agonist activity of impromidine (SK & F 92676) in anaesthetized rabbits and on the rabbit isolated fundic mucosa. Curwain, B.P., Turner, N.C. Br. J. Pharmacol. (1981) [Pubmed]
  19. Effect of impromidine (SK&F 92676) on the isolated papillary muscle of the guinea-pig. Bertaccini, G., Coruzzi, G. Br. J. Pharmacol. (1981) [Pubmed]
  20. Characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in rabbit cerebral cortical slices. Al-Gadi, M., Hill, S.J. Br. J. Pharmacol. (1985) [Pubmed]
  21. Autoregulation of histamine release in brain by presynaptic H3-receptors. Arrang, J.M., Garbarg, M., Schwartz, J.C. Neuroscience (1985) [Pubmed]
  22. The involvement of histamine receptor subtypes in gastric acid secretion and mucosal blood flow in the anaesthetized rabbit. Curwain, B.P., Turner, N.C. J. Physiol. (Lond.) (1981) [Pubmed]
  23. Characterization of histamine receptors in cat cerebral arteries in vitro and in situ. Edvinsson, L., Gross, P.M., Mohamed, A. J. Pharmacol. Exp. Ther. (1983) [Pubmed]
  24. Use of impromidine to define specific histamine H-2 effects on gastric secretion, heart rate and blood pressure in conscious dogs. Molina, E., Rentz, J., Hirschowitz, B.I. J. Pharmacol. Exp. Ther. (1980) [Pubmed]
  25. Effects of impromidine, a specific H2-receptor agonist and 2(2-pyridyl)-ethylamine, an H1-receptor agonist, on stimulation-induced release of [3H]-noradrenaline in guinea-pig isolated atria. Rand, M.J., Story, D.F., Wong-Dusting, H. Br. J. Pharmacol. (1982) [Pubmed]
  26. Biochemical, physiological and pathophysiological aspects of intestinal diamine oxidase. Biegański, T. Acta physiologica Polonica. (1983) [Pubmed]
  27. A marked H1-receptor-mediated vasodilator effect of histamine in the isolated perfused rat heart. Akar, F., Ercan, Z.S., Türker, R.K. Eur. J. Pharmacol. (1984) [Pubmed]
  28. Pharmacological characterization of histamine receptors in the human temporal artery. Ottosson, A., Jansen, I., Edvinsson, L. British journal of clinical pharmacology. (1989) [Pubmed]
  29. Histamine release in the isolated vascularly perfused stomach of the rat: regulation by autoreceptors. Sandvik, A.K., Lewin, M.J., Waldum, H.L. Br. J. Pharmacol. (1989) [Pubmed]
  30. Impromidine, a potent inhibitor of histamine methyltransferase (HMT) and diamine oxidase (DAO). Beaven, M.A., Roderick, N.B. Biochem. Pharmacol. (1980) [Pubmed]
  31. Histaminergic descending inputs to the mesopontine tegmentum and their role in the control of cortical activation and wakefulness in the cat. Lin, J.S., Hou, Y., Sakai, K., Jouvet, M. J. Neurosci. (1996) [Pubmed]
  32. Gastric acid inhibition and oxmetidine kinetics in duodenal ulcer. Gugler, R., Rohner, H.G., Somogyi, A.A. Clin. Pharmacol. Ther. (1982) [Pubmed]
  33. Interaction of histamine with noradrenergic constrictory mechanisms in cat cerebral arteries and veins. Gross, P.M., Harper, A.M., Teasdale, G.M. Can. J. Physiol. Pharmacol. (1983) [Pubmed]
  34. Evidence for presynaptic inhibitory histamine (H2) receptors in the rat hindquarter vasculature. Holcslaw, T.L., Lassiter, D. J. Cardiovasc. Pharmacol. (1987) [Pubmed]
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