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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The effect of glycerol on autotomy. An experimental model of neuralgia pain.

Autotomy in nerve injured rats has been put forward as an animal model in a broad range of chronic neuralgic pain. We have examined the effect of glycerol, a new and promising therapeutic agent for trigeminal neuralgia, on this animal model. A single dose of glycerol, alcohol or saline was injected directly into experimental sciatic nerve neuromas in rats via a chronically implanted cannula. Injections were made either at the time of nerve injury or 2 weeks afterwards. Both forms of glycerol treatment caused a significant reduction in autotomy behavior relative to saline. Alcohol also suppressed autotomy, but it was less effective than glycerol.[1]


  1. The effect of glycerol on autotomy. An experimental model of neuralgia pain. Rappaport, Z.H., Seltzer, Z., Zagzag, D. Pain (1986) [Pubmed]
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