Disease relevance of Trigeminal Neuralgia

• The syndrome of inappropriate antidiuretic hormone secretion, with marked hyponatremia, was observed in an elderly women who was taking carbamazepine for trigeminal neuralgia [1].
• Gabapentin relieves trigeminal neuralgia in multiple sclerosis patients [2].
• We conducted an open-label trial of gabapentin (GBP) as therapy for paroxysmal symptoms (PS) in 21 MS patients, including trigeminal neuralgia (6 patients), painful tonic spasms (11), dysesthetic or paresthetic symptoms (3) and ocular ataxia (1) [3].
• The efficacy of repeated nasal applications of capsaicin in cluster headache is congruent with previous reports on the therapeutic effect of capsaicin in other pain syndromes (post-herpetic neuralgia, diabetic neuropathy, trigeminal neuralgia) and supports the use of the drug to produce a selective analgesia [4].
• Carbamazepine has selectively relieved the tic douloureux, while lithium has completely controlled the cluster headache [5].

Psychiatry related information on Trigeminal Neuralgia

• Oxcarbazepine. A review of its pharmacology and therapeutic potential in epilepsy, trigeminal neuralgia and affective disorders [6].

High impact information on Trigeminal Neuralgia

• Treatment of tic douloureux by percutaneous retrogasserian glycerol injection [7].
• The initial treatment of trigeminal neuralgia is accomplished with drugs, primarily carbamazepine and occasionally phenytoin sodium [8].
• Letter: Alcohol injection for trigeminal neuralgia [9].
• Carbamazepine, a drug used widely to treat epilepsy and trigeminal neuralgia, has been shown to be effective in the acute and prophylactic treatment of manic-depressive illness [10].
• A double-blind crossover study of the effects of baclofen was conducted on 10 patients with typical trigeminal neuralgia [11].

Chemical compound and disease context of Trigeminal Neuralgia

• The results indicate that baclofen is a useful drug in the treatment of trigeminal neuralgia [11].
• An open trial in another 50 patients with trigeminal neuralgia refractory to or unable to tolerate carbamazepine showed that 37 (74%) were relieved of their attacks by baclofen, either alone (12 patients) or in combination with previously ineffective doses of carbamazepine or phenytoin (25) [11].
• There have been anecdotal reports of efficacy of lamotrigine in the treatment of painful neuropathy and trigeminal neuralgia [12].
• Gabapentin for idiopathic trigeminal neuralgia: report of two cases [13].
• Pimozide therapy for trigeminal neuralgia [14].

Biological context of Trigeminal Neuralgia

• Percutaneous retrogasserian glycerol rhizotomy for tic douloureux: Part 2. Results nd implications of trigeminal evoked potential studies [15].
• The effects of dextropropoxyphene on the steady-state kinetics of oxcarbazepine and its metabolites were investigated in eight patients with epilepsy or trigeminal neuralgia [16].

Anatomical context of Trigeminal Neuralgia

• CONCLUSION: Both FISP and MP-RAGE MR imaging are useful in demonstrating vascular contact with the trigeminal nerve at the root entry zone in patients with trigeminal neuralgia [17].
• A possible analgesic mechanism could be that tocainide blocks the sodium channels in the hyperexcitable nerve membranes in the pain-producing foci in trigeminal neuralgia [18].
• D-Baclofen reduced the response to L-baclofen in the feline trigeminal nucleus, the spinal cord of the rat and in patients with trigeminal neuralgia, but not in slices of hippocampus or neocortex [19].
• The histopathological and autonomic effects of percutaneous trigeminal ganglion compression for trigeminal neuralgia were studied in New Zealand White rabbits [20].
• To investigate the role of serotonergic, noradrenergic, dopaminergic, and peptidergic systems, we determined the concentrations of epinephrine, norepinephrine, and their breakdown product, vanillylmandelic acid, in the cerebrospinal fluid of 16 patients (55.3 +/- 8.3 years) with trigeminal neuralgia [21].

Gene context of Trigeminal Neuralgia

• Our results demonstrated that the myelin sheaths of schwann cell from the peripheral neuroectomy of trigeminal neuralgia were positively expressing mRNA of BMP-2, 3, 4 and 5 [22].
• Seventy-eight patients with tic douloureux who underwent 92 percutaneous radiofrequency trigeminal gangliolysis (PRTG) procedures were evaluated on average of 56 months postoperatively [23].
• We conclude that in MS trigeminal neuralgia is usually caused by demyelinating lesions affecting pontine trigeminal pathways [24].
• Additional trials are necessary to conclusively evaluate the efficacy of NMDA-receptor antagonists in trigeminal neuralgia [25].
• MATERIALS AND METHODS: Thirteen patients with unilateral trigeminal neuralgia and 50 control subjects underwent three-dimensional fast inflow with steady-state precession (FISP) and contrast material-enhanced magnetization-prepared rapid acquisition gradient-echo (MP-RAGE) MR imaging [17].

Analytical, diagnostic and therapeutic context of Trigeminal Neuralgia

• We have examined the effect of glycerol, a new and promising therapeutic agent for trigeminal neuralgia, on this animal model [26].
• In a double-blind study the efficacy and tolerability of tizanidine was compared with those of carbamazepine in the management of trigeminal neuralgia [27].
• Identification of Meckel cave during percutaneous glycerol rhizotomy for tic douloureux [28].
• Trigeminal Nerve-Blood Vessel Relationship as Revealed by High-resolution Magnetic Resonance Imaging and Its Effect on Pain Relief after Gamma Knife Radiosurgery for Trigeminal Neuralgia [29].
• In conclusion, carbamazepine is the mainstay of pharmacotherapy of trigeminal neuralgia, and secondary drug choices are baclofen, lamotrigine, oxcarbazepine, phenytoin, gabapentin, and sodium valproate [30].

References