The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Neuroma


Psychiatry related information on Neuroma

  • The results suggest that the presence of a phantom limb, whether painful or painless, is related to the sympathetic-efferent outflow of cutaneous vasoconstrictor fibres in the stump and stump neuromas [6].

High impact information on Neuroma

  • Disruption of Schwann cells in response to nerve lesion resulted in infiltration of CCR2-positive monocytes/macrophages not only to the neuroma but also to the DRG [7].
  • The results achieved in a rodent model of sciatic nerve neuroma formation showed that there was a positive correlation between macroscopic and microscopic observations, and that melatonin enhanced axonal regeneration presumably due to its inhibitory effect on neuroma formation [8].
  • Similar results were obtained after topical application of lidocaine to the nerve trunk to block abnormal discharges originating in the neuroma in CSNT rats [9].
  • In recordings at approximately 22 days, a similar proportion of fibres were mechanosensitive in wild-type and Nav1.8 null neuromas (51 and 46%, respectively) [10].
  • MATERIALS AND METHODS: Fifteen patients with clinically suspected Morton neuroma underwent examination with conventional T1- and T2-weighted MR imaging and a combination of fat suppression and administration of gadopentetate dimeglumine [11].

Chemical compound and disease context of Neuroma


Biological context of Neuroma

  • The results of our study suggest that TNF-alpha and IL-1 may play a role in frustrating functional nerve regeneration after injury by stimulating these two kinases, which, in turn, leads to fibroblast proliferation and formation of neuromas [16].
  • Ankyrin G, a multifunctional transmembrane protein of the axolemma, might be a key protein in neuroma formation because it binds Na+ channels in the initial segments of a regenerating axon and links with neuronal cell adhesion molecules [17].
  • Milliwatt CO2 laser application to the proximal stump did not affect the size or histology of resultant neuroma formation regardless of the method of transection [18].
  • CGRP accumulates in a time-related fashion within experimental neuromas, where it induces among other possible actions prominent local vasodilatation [19].

Anatomical context of Neuroma


Gene context of Neuroma


Analytical, diagnostic and therapeutic context of Neuroma


  1. Herpes simplex virus-mediated human hypoxanthine-guanine phosphoribosyltransferase gene transfer into neuronal cells. Palella, T.D., Silverman, L.J., Schroll, C.T., Homa, F.L., Levine, M., Kelley, W.N. Mol. Cell. Biol. (1988) [Pubmed]
  2. Epithelial membrane antigen expression by the perineurium of peripheral nerve and in peripheral nerve tumours. Theaker, J.M., Gatter, K.C., Puddle, J. Histopathology (1988) [Pubmed]
  3. Anetodermic prurigo nodularis (with Pautrier's neuroma) responsive to arotinoid acid. Hirschel-Scholz, S., Salomon, D., Merot, Y., Saurat, J.H. J. Am. Acad. Dermatol. (1991) [Pubmed]
  4. Frequent expression of 75 kDa nerve growth factor receptor and phosphotyrosine in human peripheral nerve tumours: an immunohistochemical study on paraffin-embedded tissues. Hoshi, N., Hiraki, H., Yamaki, T., Natsume, T., Watanabe, K., Suzuki, T. Virchows Arch. (1994) [Pubmed]
  5. Histopathology and growth pattern of cystic acoustic neuromas. Charabi, S., Klinken, L., Tos, M., Thomsen, J. Laryngoscope (1994) [Pubmed]
  6. Psychophysical correlates of phantom limb experience. Katz, J. J. Neurol. Neurosurg. Psychiatr. (1992) [Pubmed]
  7. Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Abbadie, C., Lindia, J.A., Cumiskey, A.M., Peterson, L.B., Mudgett, J.S., Bayne, E.K., DeMartino, J.A., MacIntyre, D.E., Forrest, M.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. Pinealectomy exaggerates and melatonin treatment suppresses neuroma formation of transected sciatic nerve in rats: gross morphological, histological and stereological analysis. Turgut, M., Uyanikgil, Y., Baka, M., Tunç, A.T., Yavaşoğlu, A., Yurtseven, M.E., Kaplan, S. J. Pineal Res. (2005) [Pubmed]
  9. Decreasing sympathetic sprouting in pathologic sensory ganglia: a new mechanism for treating neuropathic pain using lidocaine. Zhang, J.M., Li, H., Munir, M.A. Pain (2004) [Pubmed]
  10. The tetrodotoxin-resistant Na+ channel Nav1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice. Roza, C., Laird, J.M., Souslova, V., Wood, J.N., Cervero, F. J. Physiol. (Lond.) (2003) [Pubmed]
  11. Morton neuroma: evaluation with MR imaging performed with contrast enhancement and fat suppression. Terk, M.R., Kwong, P.K., Suthar, M., Horvath, B.C., Colletti, P.M. Radiology. (1993) [Pubmed]
  12. The effect of intravenous lidocaine, tocainide, and mexiletine on spontaneously active fibers originating in rat sciatic neuromas. Chabal, C., Russell, L.C., Burchiel, K.J. Pain (1989) [Pubmed]
  13. Pain response to perineuromal injection of normal saline, epinephrine, and lidocaine in humans. Chabal, C., Jacobson, L., Russell, L.C., Burchiel, K.J. Pain (1992) [Pubmed]
  14. The effect of glycerol on autotomy. An experimental model of neuralgia pain. Rappaport, Z.H., Seltzer, Z., Zagzag, D. Pain (1986) [Pubmed]
  15. PET-fluorodeoxyglucose of cranial and spinal neuromas. Borbely, K., Fulham, M.J., Brooks, R.A., Di Chiro, G. J. Nucl. Med. (1992) [Pubmed]
  16. Tumor necrosis factor-alpha and interleukin-1 induce activation of MAP kinase and SAP kinase in human neuroma fibroblasts. Lu, G., Beuerman, R.W., Zhao, S., Sun, G., Nguyen, D.H., Ma, S., Kline, D.G. Neurochem. Int. (1997) [Pubmed]
  17. Painful neuromas: a potential role for a structural transmembrane protein, ankyrin G. Kretschmer, T., Nguyen, D.H., Beuerman, R.W., Happel, L.T., England, J.D., Tiel, R.L., Kline, D.G. J. Neurosurg. (2002) [Pubmed]
  18. Comparative study of neuroma formation in the rat sciatic nerve after CO2 laser and scalpel neurectomy in combination with milliwatt CO2 laser "sealing". Shapiro, S., Woodall, B., Muller, J. Surgical neurology. (1989) [Pubmed]
  19. Evidence for CGRP accumulation and activity in experimental neuromas. Zochodne, D.W., Allison, J.A., Ho, W., Ho, L.T., Hargreaves, K., Sharkey, K.A. Am. J. Physiol. (1995) [Pubmed]
  20. In vitro characterization of a peripheral afferent pathway of the rat after chronic sciatic nerve section. Babbedge, R.C., Soper, A.J., Gentry, C.T., Hood, V.C., Campbell, E.A., Urban, L. J. Neurophysiol. (1996) [Pubmed]
  21. Axonal cross-excitation in nerve-end neuromas: comparison of A- and C-fibers. Amir, R., Devor, M. J. Neurophysiol. (1992) [Pubmed]
  22. Neuropeptide- and tyrosine hydroxylase-immunoreactive nerve fibers in painful Morton's neuromas. Lindqvist, A., Rivero-Melian, C., Turan, I., Fried, K. Muscle Nerve (2000) [Pubmed]
  23. The excitation of cutaneous nerve endings in a neuroma by capsaicin. Hartung, M., Leah, J., Zimmerman, M. Brain Res. (1989) [Pubmed]
  24. Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation. Schlegel, J., Muenkel, K., Trenkle, T., Fauser, G., Ruschoff, J. Int. J. Oncol. (1998) [Pubmed]
  25. An unusual etiology of biliary hilar obstruction and the potential role of acidic fibroblast growth factor in the development of a biliary neuroma. Pickens, A., Vickers, S.M., Brown, K.L., Reddy, V.V., Thompson, J.A. The American surgeon. (1999) [Pubmed]
  26. Traumatic neuroma of the cystic duct in the absence of previous surgery. Peison, B., Benisch, B. Hum. Pathol. (1985) [Pubmed]
  27. Peptides and neuromas: calcitonin gene-related peptide, substance P, and mast cells in a mechanosensitive human sural neuroma. Zochodne, D.W., Theriault, M., Sharkey, K.A., Cheng, C., Sutherland, G. Muscle Nerve (1997) [Pubmed]
  28. Morton neuroma: comparative results of two conservative methods. Saygi, B., Yildirim, Y., Saygi, E.K., Kara, H., Esemenli, T. Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society. (2005) [Pubmed]
WikiGenes - Universities