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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Effects of intrahypothalamically administered norepinephrine, serotonin and bombesin on thermoregulation in the deermouse (Peromyscus maniculatus).

Norepinephrine, serotonin, and bombesin administered intrahypothalamically affected thermoregulation in the deermouse, Peromyscus maniculatus. At a Ta of 22 degrees C, doses of 3 micrograms and 6 micrograms of NE resulted in transient hypothermia (maximum drop of 1.6 +/- 1.0 degrees C and 4.3 +/- 2.3 degrees C, respectively). A 1.5 microgram dose of 5-HT induced a persistent hyperthermia (maximum increase of 1.8 +/- 0.8 degrees C) which persisted for more than 2 h. A 6 microgram dose of 5-HT did not produce any significant effects. At a Ta of 22 degrees C, doses of 1 ng and 10 ng of bombesin produced a transient hyperthermia (maximum increase of 1.8 +/- 0.3 degree C and 2.1 +/- 1.2 degrees C, respectively) immediately postinjection. At a Ta of 5 degrees C, a 1 ng dose of bombesin resulted in a prolonged hypothermia (maximum decrease of 2.0 +/- 0.4 degrees C), while a 10 ng dose of bombesin produced a hyperthermic response (maximum increase of 1.3 +/- 0.8 degree C) at 2 h postinjection.[1]

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