Disease relevance of Peromyscus

• Comparison of polymerase chain reaction and culture for detection of Borrelia burgdorferi in naturally infected Peromyscus leucopus and experimentally infected C.B-17 scid/scid mice [1].
• Brevinema andersonii gen. nov., sp. nov., an infectious spirochete isolated from the short-tailed shrew (Blarina brevicauda) and the white-footed mouse (Peromyscus leucopus) [2].
• Previously, we have shown that CMV isolated from deer mouse could be used in vivo and in vitro to express Sin Nombre virus (SNV) glycoprotein G1 in deer mice [Rizvanov AA, van Geelen AG, Morzunov S, et al. Generation of a recombinant cytomegalovirus for expression of a hantavirus glycoprotein. J.Virol. 2003;77(22):12203-10] [3].
• In 1993 Sin Nombre virus was recognized as the cause of hantavirus pulmonary syndrome (HPS) and the deer mouse (Peromyscus maniculatus) was identified as the reservoir host [4].
• This study provides the first evidence that New World arenaviruses occur in Los Angeles and Orange counties and northwestern San Diego County, and the first evidence that Peromyscus and Reithrodontomys species are naturally infected with New World arenaviruses [5].

Psychiatry related information on Peromyscus

• Testosterone, paternal behavior, and aggression in the monogamous California mouse (Peromyscus californicus) [6].
• Levels of plasma oxytocin in male Peromyscus californicus were assessed across the reproductive cycle to provide a foundation for subsequent studies of the hormonal basis of paternal behavior and pair bonds [7].

High impact information on Peromyscus

• Long-term implants releasing a small quantity of melatonin (45 nanograms per day) were used to determine the brain sites of the hormone's antigonadal action in a photoperiodic species, the white-footed mouse (Peromyscus leucopus) [8].
• The role of alcohol dehydrogenase in the hepatic necrosis due to allyl alcohol was studied in two strains of the deermouse, Peromyscus maniculatus [9].
• However, both stocks of deer mice produce high levels of Adh-2 mRNA in liver [10].
• Based on calculations it was estimated that at least 50% of ethanol elimination in ADH- deer mice was caused by the action of dehydrogenase systems [11].
• Peromyscus leucopus lost DNA 5-methyldeoxycytidine residues at a rate of only 2.3 X 10(4) (approximately 0.006% of the newborn level)/month [12].

Chemical compound and disease context of Peromyscus

• Testosterone promotes paternal behavior in California mouse (Peromyscus californicus) fathers, acting primarily via aromatization to estradiol [13].
• Effects of ingestion of chlorocholine chloride and cyclophosphamide on Venezuelan equine encephalitis virus infections in deer mice (Peromyscus maniculatus) [14].
• The single dose oral LD50 for the organophosphorus insecticide azinphos-methyl (Guthion) was 10, 11, 32, and 48 mg/kg body weight in wild house mice, laboratory mice, gray-tailed voles, and deer mice, respectively [15].
• Passive application of fipronil significantly reduced the infection rate of Borrelia burgdorferi among white-footed mice by 53% [16].
• Acute toxicity and effects of sublethal dietary exposure of monosodium methanearsonate herbicide to Peromyscus leucopus (Rodentia: Cricetidae) [17].

Biological context of Peromyscus

• This cDNA encodes an amino acid sequence representing a new class of mammalian ADH, and the deer mouse gene for this ADH is named Adh-2 [10].
• Norepinephrine, serotonin, and bombesin administered intrahypothalamically affected thermoregulation in the deermouse, Peromyscus maniculatus [18].
• Diurnal rhythm of response to chronic intrahypothalamic melatonin injections in the white-footed mouse, peromyscus leucopus [19].
• In the present paper, we compare melatonin receptor distribution and a second messenger response to melatonin in white-footed mice from CT and GA [20].
• Melatonin receptors and signal transduction in melatonin-sensitive and melatonin-insensitive populations of white-footed mice (Peromyscus leucopus) [20].

Anatomical context of Peromyscus

• 2. Mitochondria from both ADH+ and ADH- deer mice catalyzed NAD+-dependent ethanol oxidation and NADH-dependent acetaldehyde reduction [11].
• Effects of photoperiod, beta-endorphin, and naloxone on in vitro secretion of testosterone in white-footed mouse (Peromyscus leucopus) testes [21].
• In the present investigation, we found significant ethanol oxidizing activity in the gastric mucosa of the deer mice [22].
• Duration of the melatonin pulse in the hypothalamus controls testicular function in pinealectomized mice (Peromyscus leucopus) [23].
• p-nitrosophenol reduction by liver cytosol from ADH-positive and -negative deermice (Peromyscus maniculatus) [24].

Associations of Peromyscus with chemical compounds

• Non-alcohol dehydrogenase-mediated metabolism of methylazoxymethanol in the deer mouse, Peromyscus maniculatus [25].
• Inhibition of methanol metabolism in deer mice expressing ADH indicates that this phenomenon also occurs in species with ADH [26].
• Ethanol can be oxidized to the 1-hydroxyethyl radical (HER) by rat and deer mice liver microsomal systems [27].
• Photoperiodic adjustments in hypothalamic amines, gonadotropin-releasing hormone, and beta-endorphin in the white-footed mouse [28].
• Differences between species included 12% more cholesterol/g total lipid extract in Peromyscus than in Mus throughout life, a linear increase with age in lipid phosphorus/g fresh weight at a faster rate in Peromyscus over Mus, and a linear increase in the total lipid extract weight throughout life in Mus but a decrease in Peromyscus [29].

Gene context of Peromyscus

• Molecular basis of the alcohol dehydrogenase-negative deer mouse. Evidence for deletion of the gene for class I enzyme and identification of a possible new enzyme class [10].
• A single gene for Hbb-y has been isolated from Peromyscus [30].
• Peromyscus animals show biallelic expression of Rasgrf1 in neonatal brain [31].
• The results indicate that the Bov-B LINE insert is present in the genomic sequences of bcnt orthologs from sheep, goats, axis deer, and mouse deer (chevrotain), that is in Ruminantia, but not in pigs or human [32].
• Isolation, purification, and characterization of deer mouse (Peromyscus maniculatus bairdii) prolactin [33].

Analytical, diagnostic and therapeutic context of Peromyscus

• Allelic heterogeneity within protein electromorphs at three loci was examined in populations of deer mice (Peromyscus maniculatus) collected from five localities across North America. We used a variety of electrophoretic techniques (including several starch and acrylamide conditions, gel-sieving, and isoelectric focusing) plus heat denaturation [34].
• We examined developmental changes in nociception and mu (morphine) and kappa (U-50,488) opiate-induced analgesia in male and female deer mice of two different populations; Peromyscus maniculatus artemisiae from a mainland region and P. m. angustus from a small island [35].
• Development and characterization of a homologous radioimmunoassay for deer mouse (Peromyscus maniculatus bairdii) prolactin [36].
• Medroxyprogesterone, immunosuppression, and conceptus size in Peromyscus [37].
• Characterization of Peromyscus MHC class II beta sequences by ligation-anchored RT-PCR and denaturing gradient gel electrophoresis [38].

References