- 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 3. 7-(3,5-Disubstituted [1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives. Stokker, G.E., Alberts, A.W., Anderson, P.S., Cragoe, E.J., Deana, A.A., Gilfillan, J.L., Hirshfield, J., Holtz, W.J., Hoffman, W.F., Huff, J.W. J. Med. Chem. (1986)