Disease relevance of hydrogen fluoride

• Hydrolysis of the meningococcal group A, B, and C, and Escherichia coli K92 polysaccharides by 60% aqueous hydrofluoric acid liberated various 1,2-diacylglycerols [1].
• In this report we describe the structure of the polysaccharide released from Bacillus anthracis vegetative cell walls by aqueous hydrogen fluoride (HF) [2].
• Fulminant acute colitis following a self-administered hydrofluoric acid enema [3].
• Cleavage of the O antigen 4, 5, 12 of Salmonella typhimurium by hydrofluoric acid [4].
• Ingestion of hydrofluoric acid could induce similar cardiac toxicity; however, reported cases of hydrofluoric acid ingestion rarely have been described, and the rapid death of these patients has not allowed verification of this hypothesis [5].

Psychiatry related information on hydrogen fluoride

• The findings show a linear relationship between the level of hydrofluoric acid exposure and the degree of psychological stress two years after the accident [6].

High impact information on hydrogen fluoride

• Deglycosylation of extracellular and intracellular prothrombin with hydrofluoric acid (HF) resulted in a decrease in mol wt for both species to 66 kd [7].
• A chemiluminescence-based enzyme-linked immunosorbent assay (ELISA) was developed to measure the kinetics of the WaaP sugar kinase activity, and the results showed that the K(m) was 0.22 mm for ATP and 14.4 microm for hydrofluoric acid-treated LPS, V(max) was 408.24 pmol min(-1), and k(cat) was 27.23 min(-1) [8].
• This analysis, which required removal of the GPI anchors by aqueous hydrofluoric acid treatment and cleavage at aspartate-proline bonds by mild acid hydrolysis, provided precise information about the glycosylation state and the number of Glu-Pro repeats in these proteins [9].
• The [3H]myo-inositol-labeled abnormal lipids were isolated and characterized using hydrofluoric acid dephosphorylation, nitrous acid deamination, acetolysis, and exoglycosidase treatments alone or in combination [10].
• This 161-Da moiety could be removed from the lipid A by treatment with aqueous hydrofluoric acid and was identified as galactosamine following peracetylation and analysis by gas chromatography-mass spectrometry [11].

Chemical compound and disease context of hydrogen fluoride

• The role of calcium gluconate in the treatment of hydrofluoric acid eye burn [12].
• Numerous reports of poisonings due to various fluoride salts and also to hydrofluoric acid have appeared in the literature [13].

Biological context of hydrogen fluoride

• The primary structure of the K2 antigen of Escherichia coli was elucidated by composition, alkaline fragmentation, dephosphorylation with hydrofluoric acid, periodate oxidation, and methylation analysis [14].
• Alkali does not affect the phosphorylation state of PHF and complete dephosphorylation of PHF with hydrofluoric acid does not affect PHF solubility [15].
• Hexafluorine is a novel liquid compound developed especially for emergency decontamination of hydrofluoric acid eye and skin exposures [16].
• RESULTS: A previously healthy 26-year-old woman developed asthma immediately following inhalation exposure to hydrofluoric acid from a household cleaner, consistent with reactive airways dysfunction syndrome [17].
• Occupational medicine in Oklahoma: hydrofluoric acid dangers [18].

Anatomical context of hydrogen fluoride

• Regional intravenous infusion of calcium gluconate for hydrofluoric acid burns of the upper extremity [19].
• A patient with a 70% hydrofluoric acid burn developed systemic dissemination of fluoride ion from a 9% to 10% body surface area exposure on the lower extremities [20].
• Oxidative conversion of 6-fluorobenzo(c)phenanthrene to its K-region oxide by liver microsomes from 3-methylcholanthrene treated rats: reversal of stereoselectivity of cytochrome P-450c due to the influence of fluoro group [21].
• Surface characteristics of dentin experimentally exposed to hydrofluoric acid [22].
• Pathological demonstration of rapid involvement into the subcutaneous tissue in a case of fatal hydrofluoric acid burns [23].

Associations of hydrogen fluoride with other chemical compounds

• The most abundant glycolipid of SIA-b cells (named lipid X) was isolated and partially characterized using hydrofluoric acid, nitrous acid deamination, acetolysis, and exoglycosidase treatments alone or in combination [24].
• The GLC/MS assay employed phospholipase C or hydrofluoric acid for hydrolysis of the phosphocholine moiety to yield ether monoglycerides [25].
• Cell walls of C. thermocellum lost their affinity for SLH domains after treatment with 48% hydrofluoric acid but not after treatment with formamide or dilute acid [26].
• For the in vivo experiment, hydrofluoric acid burns were induced by dispensing 50% hydrofluoric acid (50 microL) on the backs of the nude rats, who were under pentobarbital anesthesia [27].
• For the monosaccharide composition, the polysaccharides were subjected to hydrofluoric acid (HF) hydrolysis followed by trifluoroacetic acid (TFA) [28].

Gene context of hydrogen fluoride

• The beta-1,6-glucan moiety could be removed from Cwp1p and other cell wall proteins by cleaving phosphodiester bridges either enzymatically using phosphodiesterases or chemically using ice-cold aqueous hydrofluoric acid [29].
• The concentration of hydrofluoric acid (HF) was optimized to obtain an optically flat surface which was evaluated by AFM, SEM and dark-field microscopy [30].
• The anionic species were successively neutralized by neuraminidase (29%), aq. hydrofluoric acid (30%), and methanolysis (26%), indicating that approximately equal portions were sensitive to desialylation, dephosphorylation and desulfation, respectively [31].
• However, if these LPS were dephosphorylated with aqueous hydrofluoric acid (HF) their KDO response in this assay was increased 5.4- to 2.6-fold, respectively [32].
• Peri- and subungual burns caused by hydrofluoric acid [33].

Analytical, diagnostic and therapeutic context of hydrogen fluoride

• The lipids were isolated, and their carbohydrate moiety was characterized using hydrofluoric acid dephosphorylation, nitrous acid deamination, acetolysis, exoglycosidase treatments, and combinations thereof to produce labeled fragments which could be analyzed by paper chromatography [34].
• This simple method of gap construction requires no micromanipulation under a microscope, hydrofluoric acid etching, or use of column fittings [35].
• The high-voltage end of the electrophoresis capillary has been etched with hydrofluoric acid to form a microinjector [36].
• They lost their beta-1,6-glucan epitope after treatment with ice-cold aqueous hydrofluoric acid, suggesting that beta-1,6-glucan was linked to the protein through a phosphodiester bridge [37].
• This efficacy of iontophoresis was observed when it was initiated within 30 mins after hydrofluoric acid burn [27].

References