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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Sensitivity and subsequent "down regulation" of sensitivity induced by chlorocresol in guinea pigs.

Chlorocresol was shown to have great potential for contact sensitization in the guinea-pig maximization test at the Day-21 challenge; 2 weeks later, the reactivity was significantly decreased. Cyclophosphamide (250 mg/kg) was interperitoneally injected and used as a modulator for the immune response. When cyclophosphamide was administered 3 days before the first challenge, the decrease in reactivity from Day 21 to Day 35 was reversed. This indicates that the reduction in sensitivity was caused by an immunologic mechanism--probably the formation of suppressor cells. This phenomenon is called the "down regulation" of sensitivity and may operate in eczema patients who have lost patch-test reactivity.[1]


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