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Divicine induces calcium release from rat liver mitochondria.

Divicine, a pyrimidine aglycone strongly implicated in the pathogenesis of favism, induces calcium release from intact rat liver mitochondria. Divicine-dependent calcium release is accompanied by oxidation and hydrolysis of intramitochondrial pyridine nucleotides. Inhibition of both mitochondrial glutathione peroxidase and glutathione reductase slows down divicine-induced calcium release. Cyanide-insensitive respiration indicates redox cycling of divicine in mitochondria. The results suggest that attention should be paid to the action of divicine in cells other than red blood cells.[1]


  1. Divicine induces calcium release from rat liver mitochondria. Graf, M., Frei, B., Winterhalter, K.H., Richter, C. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
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