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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Acid and hyperosmolal solutions in the upper intestine of chronic gastric fistula rats inhibit gastric acid secretion by different mechanisms.

In chronic gastric fistula rats 0.20 M HCl and 1200 mOsm X kg-1 solution of polyethylene glycol (PEG) infused into a duodenal loop anastomosed to the jejunum (Roux-en-Y) produced maximal inhibition of pentagastrin-stimulated acid secretion, which amounted to 60% and 50%, respectively. In the present study in Roux-en-Y rats with gastric fistula, perfusion of the loop with hyperosmolal (1200 mOsm X kg-1 of PEG solution) 0.20 M HCl produced a greater reduction of the maximal response to pentagastrin (91% inhibition) than perfusion with 0.20 M HCl (64%), suggesting that HCl and hyperosmolal solution inhibit secretion by different mechanisms. The maximal acid response to histamine was more resistant to inhibition than that to pentagastrin; 0.20 M HCl inhibited secretion by 43%, 1200 mOsm X kg-1 of PEG solution by 42%, and hyperosmolal 0.20 M HCl by 60%. The results suggest that HCl and hyperosmolal solution also inhibit histamine-stimulated secretion by different mechanisms. The anatomical sites of the mechanisms remain to be established.[1]

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