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MeSH Review

Gastric Fistula

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Disease relevance of Gastric Fistula


Psychiatry related information on Gastric Fistula


High impact information on Gastric Fistula


Chemical compound and disease context of Gastric Fistula


Biological context of Gastric Fistula

  • In additional studies, pretreatment with L-364,718 did not significantly reverse the inhibitory effects of a fatty acid salt (sodium oleate) upon gastric emptying in gastric fistula dogs [15].
  • Loss of circadian rhythm in luminal acidity of canine stomach by implantation of a gastric fistula [16].
  • The selective cholecystokinin (CCK)-B-receptor agonist and antagonist, BC 264 and L 365260, respectively, and the CCK-A-receptor antagonist, L 364718, were used to investigate the possible involvement of different classes of CCK receptors in the control of food intake induced by exogenous CCK octapeptide (CCK-8) in the cat with gastric fistula [17].

Anatomical context of Gastric Fistula


Gene context of Gastric Fistula

  • The actions of progressive doses of intraperitoneally (IP) administered somatostatin-14 (SS-14) and -28 (SS-28) on gastric secretion (acid, pepsin) and mucosal blood flow (MBF) were studied in conscious gastric fistula rats both under basal conditions and under additional administration of pentagastrin [23].
  • Intracerebroventricular injection of IL-1 beta (100 ng) decreased acid secretion in pylorus-ligated rats and inhibited basal and pentagastrin-stimulated acid secretion in rats with chronic gastric fistula [24].
  • 4. In fasted, antrally denervated rats with a gastric fistula, basal gastric acid secretion was depressed 3-fold, and plasma gastrin concentrations were similar to controls [25].
  • In this study we investigated the effect of intravenous PACAP on gastric acid secretion in conscious pylorus-ligated rats and in gastric fistula rats [26].
  • In order to further investigate this suppressive effect, somatostatin derivatives were injected to cats bearing a cannulated gastric fistula under pentagastrin stimulation [27].

Analytical, diagnostic and therapeutic context of Gastric Fistula

  • Finally, comparison of the acid secretory response to portal and systemic intravenous infusion of the extract in acute gastric fistula rats demonstrated significant inactivation by passage through the liver, in contrast to the results of similar studies of hog gastrin [28].
  • Intravenous injection of the CGRP receptor antagonist, CGRP(8-37) (128 nmol/kg) or the CGRP antibody #4901 (4.8 mg/kg, IV) completely prevented alpha-CGRP (3.9 nmol/kg/h)-induced inhibition of acid response to pentagastrin in urethane-anesthetized rats with gastric fistula [29].
  • The animals were equipped with a gastric fistula, fully innervated, and a Heidenhain pouch, vagally denervated, during a continuous perfusion of pentagastrin (PG) 2 microg/kg. h and vasoactive intestinal peptide (VIP) 4 microg/kg. h [30].
  • The purpose of the present study was to evaluate the effect of dopamine on gastric antral motility in conscious dogs with gastric fistula, using intraluminal strain-gauge transducers [31].
  • Tissue from the oxyntic gland area was obtained by introduction of an endoscope through a gastric fistula, and biopsies were taken before, after 4 weeks of oral administration of omeprazole and 1 month after withdrawal of the drug [32].


  1. Synthesis of the C-terminal octapeptide of pig oxyntomodulin. Lys-Arg-Asn-Lys-Asn-Asn-Ile-Ala: a potent inhibitor of pentagastrin-induced acid secretion. Audousset-Puech, M.P., Jarrousse, C., Dubrasquet, M., Aumelas, A., Castro, B., Bataille, D., Martinez, J. J. Med. Chem. (1985) [Pubmed]
  2. Water extracts of Helicobacter pylori delay healing of chronic gastric ulcers in rats: role of cytokines and gastrin-somatostatin link. Brzozowski, T., Konturek, P.C., Konturek, S.J., Kwiecien, S., Pajdo, R., Karczewska, E., Stachura, J., Hahn, E.G. Digestion (1999) [Pubmed]
  3. Gastric restrictive procedures to treat obesity: reasons for failure and long-term evaluation of the results of operative revision. Kaminski, D.L. International journal of surgical investigation. (2001) [Pubmed]
  4. Comparison of the step-dose and single-dose acid response to histamine and pentagastrin in chronic gastric fistula rats. Pascaud, X.B., Roger, A.R., Genton, M.J. Digestion (1977) [Pubmed]
  5. Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor. Taché, Y., Goto, Y., Gunion, M.W., Vale, W., River, J., Brown, M. Science (1983) [Pubmed]
  6. Central neurotensin inhibits gastric acid secretion: an adrenergic mechanism in rats. Zhang, L., Xing, L.P., Demers, L., Washington, J., Kauffman, G.L. Gastroenterology (1989) [Pubmed]
  7. Medullary sites of action of the TRH analogue, RX 77368, for stimulation of gastric acid secretion in the rat. Ishikawa, T., Yang, H., Taché, Y. Gastroenterology (1988) [Pubmed]
  8. Calcitonin gene-related peptide: potent peripheral inhibitor of gastric acid secretion in rats and dogs. Taché, Y., Pappas, T., Lauffenburger, M., Goto, Y., Walsh, J.H., Debas, H. Gastroenterology (1984) [Pubmed]
  9. Role of submandibular saliva and epidermal growth factor in gastric cytoprotection. Olsen, P.S., Poulsen, S.S., Kirkegaard, P., Nexø, E. Gastroenterology (1984) [Pubmed]
  10. Fundic inhibition of acid secretion and gastrin release in the dog. Soon-Shiong, P., Debas, H.T. Gastroenterology (1980) [Pubmed]
  11. Inhibition of gastric acid secretion by omeprazole in the dog and rat. Larsson, H., Carlsson, E., Junggren, U., Olbe, L., Sjöstrand, S.E., Skånberg, I., Sundell, G. Gastroenterology (1983) [Pubmed]
  12. Inhibition of gastric acid secretion in rats and in dogs by corticotropin-releasing factor. Taché, Y., Goto, Y., Gunion, M., Rivier, J., Debas, H. Gastroenterology (1984) [Pubmed]
  13. After vagotomy atropine suppresses gastrin release by food. Debas, H.T., Walsh, J.H., Grossman, M.I. Gastroenterology (1976) [Pubmed]
  14. Chemicals bathing the oxyntic gland area stimulate acid secretion in dog. Debas, H.T., Grossman, M.I. Gastroenterology (1975) [Pubmed]
  15. Roles of endogenous cholecystokinin in biliary, pancreatic and gastric function: studies with L-364,718, a specific cholecystokinin receptor antagonist. Pendleton, R.G., Bendesky, R.J., Schaffer, L., Nolan, T.E., Gould, R.J., Clineschmidt, B.V. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  16. Loss of circadian rhythm in luminal acidity of canine stomach by implantation of a gastric fistula. Postius, S., Bräuer, U. Digestion (1995) [Pubmed]
  17. Cholecystokinin-A receptor mediation of food intake in cats. Bado, A., Durieux, C., Moizo, L., Roques, B.P., Lewin, M.J. Am. J. Physiol. (1991) [Pubmed]
  18. Endogenous prostaglandins and stimulated gastric secretion in the cat: the effect of various secretory inhibitors. Baker, R., Jaffe, B.M., Reed, J.D., Shaw, B., Venables, C.W. J. Physiol. (Lond.) (1979) [Pubmed]
  19. The role of motilin in periodic interdigestive pancreatic secretion in dogs. Magee, D.F., Naruse, S. J. Physiol. (Lond.) (1984) [Pubmed]
  20. Effects of the sympathetic nervous system on bethanechol-induced elevation of gastric acid secretion and mucosal blood flow in rats. Yokotani, K., Muramatsu, I., Fujiwara, M. J. Pharmacol. Exp. Ther. (1983) [Pubmed]
  21. Capsaicin-sensitive vagal afferents contribute to gastric acid and vascular responses to intracisternal TRH analog. Raybould, H.E., Holzer, P., Reddy, S.N., Yang, H., Taché, Y. Peptides (1990) [Pubmed]
  22. Acid and hyperosmolal solutions in the upper intestine of chronic gastric fistula rats inhibit gastric acid secretion by different mechanisms. Wallin, C., Emås, S., Nylander, G. Scand. J. Gastroenterol. (1985) [Pubmed]
  23. Gastric secretion and gastrin under progressive doses of somatostatin-14 and -28 administered intraperitoneally to the rat. Seefried, G., Schmidtler, J., Schwille, P.O. Peptides (1988) [Pubmed]
  24. Central interleukin-1 beta-induced inhibition of acid secretion in rats: specificity of action. Saperas, E., Taché, Y. Life Sci. (1993) [Pubmed]
  25. Increased sensitivity of gastrin cells to gastric distension following antral denervation in the rat. Higham, A., Noble, P., Thompson, D.G., Dockray, G.J. J. Physiol. (Lond.) (1997) [Pubmed]
  26. Effect of PACAP on gastric acid secretion in rats. Mungan, Z., Hammer, R.A., Akarca, U.S., Komaki, G., Ertan, A., Arimura, A. Peptides (1995) [Pubmed]
  27. Somatostatin structure-activity studies in the stomach. Hirst, B.H., Botana, L.M., Arilla, E., Coy, D.H. Horm. Res. (1988) [Pubmed]
  28. Further evidence for an intestinal phase hormone that stimulates gastric acid secretion. Orloff, M.J., Charters, A.C., Nakaji, N.T. Surgery (1976) [Pubmed]
  29. CGRP antagonists enhance gastric acid secretion in 2-h pylorus-ligated rats. Kato, K., Martinez, V., St Pierre, S., Taché, Y. Peptides (1995) [Pubmed]
  30. Inhibitory effect of sorbin on pepsin secretion in conscious cats and rabbits. Charpin-Elhamri, G., Elbaba, M., Descroix-Vagne, M., Pansu, D., Perret, J.P. Peptides (2000) [Pubmed]
  31. Effect of dopamine on bethanechol-stimulated gastric antral motility in dogs with gastric fistula. Bech, K., Hovendal, C.P. Scand. J. Gastroenterol. (1982) [Pubmed]
  32. Effect of high-dose omeprazole administration on histamine storage and formation in canine gastric mucosa. Lundell, L., Rosengren, E., Sundell, G., Wingren, U. Digestion (1987) [Pubmed]
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