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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Experimental chemotherapy of histoplasmosis in nude mice.

Nude (nu/nu) mice were infected with Histoplasma capsulatum and treated with varying doses of 3 drug regimens: oral ambruticin, intraperitoneal amphotericin B, and amphotericin B plus oral rifampin. Therapy with amphotericin B alone was the most effective regimen. High-dose ambruticin (50 mg/kg of body weight every 8 hours) led to significantly prolonged survival compared to that of untreated control animals, but no long-term cures. Addition of rifampin produced no benefit and might actually have decreased the efficacy of amphotericin B; this combination may be deleterious in a setting of immunodeficiency.[1]


  1. Experimental chemotherapy of histoplasmosis in nude mice. Williams, D.M., Graybill, J.R., Drutz, D.J. Am. Rev. Respir. Dis. (1979) [Pubmed]
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