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MeSH Review


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Disease relevance of Histoplasma


High impact information on Histoplasma


Chemical compound and disease context of Histoplasma


Biological context of Histoplasma


Anatomical context of Histoplasma


Associations of Histoplasma with chemical compounds


Gene context of Histoplasma


Analytical, diagnostic and therapeutic context of Histoplasma


  1. Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of intracellular iron and is therapeutic in a murine model of histoplasmosis. Newman, S.L., Gootee, L., Brunner, G., Deepe, G.S. J. Clin. Invest. (1994) [Pubmed]
  2. Progressive disseminated histoplasmosis; favorable response to ketoconazole. Hawkins, S.S., Gregory, D.W., Alford, R.H. Ann. Intern. Med. (1981) [Pubmed]
  3. Distinct CD8 T cell functions mediate susceptibility to histoplasmosis during chronic viral infection. Wu-Hsieh, B.A., Whitmire, J.K., de Fries, R., Lin, J.S., Matloubian, M., Ahmed, R. J. Immunol. (2001) [Pubmed]
  4. Amphotericin B combined with itraconazole or fluconazole for treatment of histoplasmosis. LeMonte, A.M., Washum, K.E., Smedema, M.L., Schnizlein-Bick, C., Kohler, S.M., Wheat, L.J. J. Infect. Dis. (2000) [Pubmed]
  5. Interleukin-12 neutralization alters lung inflammation and leukocyte expression of CD80, CD86, and major histocompatibility complex class II in mice infected with Histoplasma capsulatum. Cain, J.A., Deepe, G.S. Infect. Immun. (2000) [Pubmed]
  6. Possible role for cysteine biosynthesis in conversion from mycelial to yeast form of Histoplasma capsulatum. Boguslawski, G., Akagi, J.M., Ward, L.G. Nature (1976) [Pubmed]
  7. Irreversible block of the mycelial-to-yeast phase transition of Histoplasma capsulatum. Medoff, G., Sacco, M., Maresca, B., Schlessinger, D., Painter, A., Kobayashi, G.S., Carratu, L. Science (1986) [Pubmed]
  8. CD40 ligand is not essential for induction of type 1 cytokine responses or protective immunity after primary or secondary infection with histoplasma capsulatum. Zhou, P., Seder, R.A. J. Exp. Med. (1998) [Pubmed]
  9. Histoplasma capsulatum modulates the acidification of phagolysosomes. Eissenberg, L.G., Goldman, W.E., Schlesinger, P.H. J. Exp. Med. (1993) [Pubmed]
  10. Role of the adherence-promoting receptors, CR3, LFA-1, and p150,95, in binding of Histoplasma capsulatum by human macrophages. Bullock, W.E., Wright, S.D. J. Exp. Med. (1987) [Pubmed]
  11. Clearance of fungal burden during treatment of disseminated histoplasmosis with liposomal amphotericin B versus itraconazole. Wheat, L.J., Cloud, G., Johnson, P.C., Connolly, P., Goldman, M., Le Monte, A., Fuller, D.E., Davis, T.E., Hafner, R. Antimicrob. Agents Chemother. (2001) [Pubmed]
  12. Antifungal therapy and the new azole compounds. Hay, R.J. J. Antimicrob. Chemother. (1991) [Pubmed]
  13. Endemic mycoses: a treatment update. Lortholary, O., Denning, D.W., Dupont, B. J. Antimicrob. Chemother. (1999) [Pubmed]
  14. Correlation of Histoplasma capsulatum polysaccharide antigen with the severity of infection in murine histoplasmosis. Williams, B.J., Connolly-Stringfield, P., Bartlett, M., Durkin, M., Garringer, T., Blair, R., Connolly, K., Tewari, R.P., Wheat, L.J. J. Clin. Lab. Anal. (1991) [Pubmed]
  15. Orbital histoplasmosis due to Histoplasma capsulatum var. duboisii: successful treatment with Septrin. Ajayi, B.G., Osuntokun, B., Olurin, O., Kale, O.O., Junaid, T.A. The Journal of tropical medicine and hygiene. (1986) [Pubmed]
  16. Role of cysteine in regulating morphogenesis and mitochondrial activity in the dimorphic fungus Histoplasma capsulatum. Maresca, B., Lambowitz, A.M., Kumar, V.B., Grant, G.A., Kobayashi, G.S., Medoff, G. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  17. In vivo generation of linear plasmids with addition of telomeric sequences by Histoplasma capsulatum. Woods, J.P., Goldman, W.E. Mol. Microbiol. (1992) [Pubmed]
  18. RNA interference in Histoplasma capsulatum demonstrates a role for alpha-(1,3)-glucan in virulence. Rappleye, C.A., Engle, J.T., Goldman, W.E. Mol. Microbiol. (2004) [Pubmed]
  19. Nitric oxide synthase expression in macrophages of Histoplasma capsulatum-infected mice is associated with splenocyte apoptosis and unresponsiveness. Wu-Hsieh, B.A., Chen, W., Lee, H.J. Infect. Immun. (1998) [Pubmed]
  20. Monitoring phase-specific gene expression in Histoplasma capsulatum with telomeric GFP fusion plasmids. Kügler, S., Young, B., Miller, V.L., Goldman, W.E. Cell. Microbiol. (2000) [Pubmed]
  21. Human dendritic cell (DC)-based anti-infective therapy: engineering DCs to secrete functional IFN-gamma and IL-12. Ahuja, S.S., Mummidi, S., Malech, H.L., Ahuja, S.K. J. Immunol. (1998) [Pubmed]
  22. Vaccination with recombinant heat shock protein 60 from Histoplasma capsulatum protects mice against pulmonary histoplasmosis. Gomez, F.J., Allendoerfer, R., Deepe, G.S. Infect. Immun. (1995) [Pubmed]
  23. Pulmonary V beta 4+ T cells from Histoplasma capsulatum-infected mice respond to a homologue of Sec31 that confers a protective response. Scheckelhoff, M.R., Deepe, G.S. J. Infect. Dis. (2006) [Pubmed]
  24. Comparison of the echinocandin caspofungin with amphotericin B for treatment of histoplasmosis following pulmonary challenge in a murine model. Kohler, S., Wheat, L.J., Connolly, P., Schnizlein-Bick, C., Durkin, M., Smedema, M., Goldberg, J., Brizendine, E. Antimicrob. Agents Chemother. (2000) [Pubmed]
  25. Tumor necrosis factor-alpha plays a role in host defense against Histoplasma capsulatum. Smith, J.G., Magee, D.M., Williams, D.M., Graybill, J.R. J. Infect. Dis. (1990) [Pubmed]
  26. Chloroquine and the fungal phagosome. Weber, S.M., Levitz, S.M., Harrison, T.S. Curr. Opin. Microbiol. (2000) [Pubmed]
  27. Ketoconazole-responsive tonsillar infection due to Histoplasma capsulatum in an HIV-1-seropositive individual. Mello, K.A., Wheat, L.J., Lis, R., Donnelly, B., Skolnik, P.R. AIDS (1991) [Pubmed]
  28. Single-dose AmBisome (Liposomal amphotericin B) as prophylaxis for murine systemic candidiasis and histoplasmosis. Garcia, A., Adler-Moore, J.P., Proffitt, R.T. Antimicrob. Agents Chemother. (2000) [Pubmed]
  29. Hypothesis on the mechanism of resistance to fluconazole in Histoplasma capsulatum. Wheat, J., Marichal, P., Vanden Bossche, H., Le Monte, A., Connolly, P. Antimicrob. Agents Chemother. (1997) [Pubmed]
  30. Comparison of nikkomycin Z with amphotericin B and itraconazole for treatment of histoplasmosis in a murine model. Goldberg, J., Connolly, P., Schnizlein-Bick, C., Durkin, M., Kohler, S., Smedema, M., Brizendine, E., Hector, R., Wheat, J. Antimicrob. Agents Chemother. (2000) [Pubmed]
  31. Regulation of immunoproteasome subunit expression in vivo following pathogenic fungal infection. Barton, L.F., Cruz, M., Rangwala, R., Deepe, G.S., Monaco, J.J. J. Immunol. (2002) [Pubmed]
  32. Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10. Deepe, G.S., Gibbons, R.S. J. Immunol. (2003) [Pubmed]
  33. Perforin is required for primary immunity to Histoplasma capsulatum. Zhou, P., Freidag, B.L., Caldwell, C.C., Seder, R.A. J. Immunol. (2001) [Pubmed]
  34. Regulation of infection with Histoplasma capsulatum by TNFR1 and -2. Allendoerfer, R., Deepe, G.S. J. Immunol. (2000) [Pubmed]
  35. Life-threatening histoplasmosis complicating immunotherapy with tumor necrosis factor alpha antagonists infliximab and etanercept. Lee, J.H., Slifman, N.R., Gershon, S.K., Edwards, E.T., Schwieterman, W.D., Siegel, J.N., Wise, R.P., Brown, S.L., Udall, J.N., Braun, M.M. Arthritis Rheum. (2002) [Pubmed]
  36. Comparison of ketoconazole and amphotericin B in interference with thymidine uptake by and blastogenesis of lymphocytes stimulated with Histoplasma capsulatum antigens. Alford, R.H., Cartwright, B.B. Antimicrob. Agents Chemother. (1983) [Pubmed]
  37. A protective domain of heat-shock protein 60 from Histoplasma capsulatum. Deepe, G.S., Gibbons, R., Brunner, G.D., Gomez, F.J. J. Infect. Dis. (1996) [Pubmed]
  38. Gel shift assay of nuclear extracts from Histoplasma capsulatum demonstrates the presence of several DNA binding proteins. Ignatov, A., Keath, E.J. Infect. Immun. (2002) [Pubmed]
  39. Evaluation of cross-reactions in Histoplasma capsulatum serologic tests. Wheat, J., French, M.L., Kamel, S., Tewari, R.P. J. Clin. Microbiol. (1986) [Pubmed]
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