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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Gangliosides as markers for murine lymphocyte subpopulations.

Antibodies to GM1 ganglioside were used to study murine lymphocyte populations. In A, AKR, and BALB/c mice, anti-GM1 reacts with thymocytes and peripheral T cells. This reactivity of anti-GM1, studied by immunofluorescence, is independent of Thy-1 type and appears to be related to the reactivity of cross-reacting antibodies to asialo GM1 and GD1b, rather than GM1 itself. In addition, a subpopulation of lymphocytes reacting with anti-GM1 and anti-immunoglobulin has been found in approximately 26% of the peripheral lymphocytes of C3H mice, nude mice, and nude heterozygotes. This subpopulation is found in small numbers in A, AKR, and BALB/c mice. These studies demonstrate that antibodies to a chemically defined antigen can be used to identify T cells in many strains of mice and may delineate previously unrecognized lymphocyte subpopulations.[1]


  1. Gangliosides as markers for murine lymphocyte subpopulations. Stein-Douglas, K., Schwarting, G.A., Naiki, M., Marcus, D.M. J. Exp. Med. (1976) [Pubmed]
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