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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Identification of a glutathione conjugate of cambendazole formed in the presence of liver microsomes.

The incubation of multiply labeled (2H, 3H, 13C, 14C) cambendazole and glutathione with hepatic microsomes from phenobarbital-dosed hamsters results in the formation of polar metabolites. The major metabolite has been characterized by a variety of isotopic, spectrometric, chromatographic, and degradative/synthetic techniques as a glutathione conjugate of cambendazole in which substitution is on the 4-position of the benzimidazole nucleus. The same metabolite is produced by hepatic microsomes from the rat.[1]

References

  1. Identification of a glutathione conjugate of cambendazole formed in the presence of liver microsomes. Wolf, D.E., VandenHeuvel, J.A., Tyler, T.R., Walker, R.W., Koniuszy, F.R., Gruber, V., Arison, B.H., Rosegay, A., Jacob, T.A., Wolf, F.J. Drug Metab. Dispos. (1980) [Pubmed]
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