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Chemical Compound Review

Azindole     1H-benzoimidazole

Synonyms: Azaindole, Benzimidazol, BENZIMIDAZOLE, Benziminazole, Benzoimidazole, ...
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Disease relevance of BENZIMIDAZOLE


Psychiatry related information on BENZIMIDAZOLE


High impact information on BENZIMIDAZOLE


Chemical compound and disease context of BENZIMIDAZOLE


Biological context of BENZIMIDAZOLE


Anatomical context of BENZIMIDAZOLE


Associations of BENZIMIDAZOLE with other chemical compounds

  • To demonstrate therapeutic efficacy in vivo, hamsters infected with A. ceylanicum were treated with three daily oral doses of purified Cry5B, the benzimidazole anthelminthic mebendazole, or buffer [27].
  • In this report, we describe an unusual example of a structural rearrangement near a buried artificial cavity in cytochrome c peroxidase that occurs on binding protonated benzimidazole [28].
  • Our clinical trial with albendazole, one of the benzimidazole carbamates, has included 26 cases of AE since September 1988, each of whom had undergone an operation [29].
  • The kinetically obtained pKa values of 6.94 +/- 0.02, 6.93 +/- 0.03, and 5.60 +/- 0.05 for imidazole, methylimidazole, and benzimidazole, respectively, match the values obtained by titrimetric pKa determination, indicating the requirement for an unprotonated nitrogen for binding to QC [30].
  • The usefulness of parbendazole and other benzimidazole carbamates as inhibitors of microtubule functions is discussed [31].

Gene context of BENZIMIDAZOLE


Analytical, diagnostic and therapeutic context of BENZIMIDAZOLE


  1. Comparison of flubendazole and diethylcarbamazine in treatment of onchocerciasis. Dominguez-Vazquez, A., Taylor, H.R., Greene, B.M., Ruvalcaba-Macias, A.M., Rivas-Alcala, A.R., Murphy, R.P., Beltran-Hernandez, F. Lancet (1983) [Pubmed]
  2. Historical perspectives on inotropic agents. Farah, A.E. Circulation (1986) [Pubmed]
  3. Physical change in cytoplasmic messenger ribonucleoproteins in cells treated with inhibitors of mRNA transcription. Dreyfuss, G., Adam, S.A., Choi, Y.D. Mol. Cell. Biol. (1984) [Pubmed]
  4. Treatment of acid-peptic diseases by inhibition of gastric H+,K+-ATPase. McArthur, K.E., Jensen, R.T., Gardner, J.D. Annu. Rev. Med. (1986) [Pubmed]
  5. Liarozole and 13-cis-retinoic acid anti-prostatic tumor activity. Stearns, M.E., Wang, M., Fudge, K. Cancer Res. (1993) [Pubmed]
  6. Genetic analysis of a relationship between macrocyclic lactone and benzimidazole anthelmintic selection on Haemonchus contortus. de Lourdes Mottier, M., Prichard, R.K. Pharmacogenet. Genomics (2008) [Pubmed]
  7. Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease. Okamura, N., Suemoto, T., Furumoto, S., Suzuki, M., Shimadzu, H., Akatsu, H., Yamamoto, T., Fujiwara, H., Nemoto, M., Maruyama, M., Arai, H., Yanai, K., Sawada, T., Kudo, Y. J. Neurosci. (2005) [Pubmed]
  8. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Chen, R.H., Waters, J.C., Salmon, E.D., Murray, A.W. Science (1996) [Pubmed]
  9. A comparative study of the effects of certain halogenated benzimidazole ribosides on RNA synthesis, cell proliferation, and interferon production. Tamm, I., Sehgal, P.B. J. Exp. Med. (1977) [Pubmed]
  10. Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450. Diaz, D., Fabre, I., Daujat, M., Saint Aubert, B., Bories, P., Michel, H., Maurel, P. Gastroenterology (1990) [Pubmed]
  11. Effects of substituted benzimidazole (H 149/94) on gastric acid secretion in humans. Olbe, L., Haglund, U., Leth, R., Lind, T., Cederberg, C., Ekenved, G., Elander, B., Fellenius, E., Lundborg, P., Wallmark, B. Gastroenterology (1982) [Pubmed]
  12. Resistance of human cytomegalovirus to the benzimidazole L-ribonucleoside maribavir maps to UL27. Komazin, G., Ptak, R.G., Emmer, B.T., Townsend, L.B., Drach, J.C. J. Virol. (2003) [Pubmed]
  13. Enantioselective analysis of albendazole sulfoxide in cerebrospinal fluid by capillary electrophoresis. Paias, F.O., Lanchote, V.L., Takayanagui, O.M., Bonato, P.S. Electrophoresis (2001) [Pubmed]
  14. Focus on new drugs in development against human cytomegalovirus. Emery, V.C., Hassan-Walker, A.F. Drugs (2002) [Pubmed]
  15. Structure-activity relationships for 5-substituted 1-phenylbenzimidazoles as selective inhibitors of the platelet-derived growth factor receptor. Palmer, B.D., Kraker, A.J., Hartl, B.G., Panopoulos, A.D., Panek, R.L., Batley, B.L., Lu, G.H., Trumpp-Kallmeyer, S., Hollis Showalter, H.D., Denny, W.A. J. Med. Chem. (1999) [Pubmed]
  16. Mechanism of action of the ribopyranoside benzimidazole GW275175X against human cytomegalovirus. Underwood, M.R., Ferris, R.G., Selleseth, D.W., Davis, M.G., Drach, J.C., Townsend, L.B., Biron, K.K., Boyd, F.L. Antimicrob. Agents Chemother. (2004) [Pubmed]
  17. The kinetics of benzimidazole dissociation in methylcobalamin. Milton, P.A., Brown, T.L. J. Am. Chem. Soc. (1977) [Pubmed]
  18. DNA sequence dependent monomer-dimer binding modulation of asymmetric benzimidazole derivatives. Tanious, F.A., Hamelberg, D., Bailly, C., Czarny, A., Boykin, D.W., Wilson, W.D. J. Am. Chem. Soc. (2004) [Pubmed]
  19. DNA minor groove recognition of a non-self-complementary AT-rich sequence by a tris-benzimidazole ligand. Aymami, J., Nunn, C.M., Neidle, S. Nucleic Acids Res. (1999) [Pubmed]
  20. Resistance of human cytomegalovirus to benzimidazole ribonucleosides maps to two open reading frames: UL89 and UL56. Krosky, P.M., Underwood, M.R., Turk, S.R., Feng, K.W., Jain, R.K., Ptak, R.G., Westerman, A.C., Biron, K.K., Townsend, L.B., Drach, J.C. J. Virol. (1998) [Pubmed]
  21. S6 phosphorylation accompanies recruitment of ribosomes and mRNA into polysomes in response to dichlororibofuranosyl benzimidazole. Duncan, R., McConkey, E.H. Exp. Cell Res. (1984) [Pubmed]
  22. Stimulation of Ca++ binding and ATPase activity of dog cardiac myofibrils by AR-L 115BS, a novel cardiotonic agent. Solaro, R.J., Rüegg, J.C. Circ. Res. (1982) [Pubmed]
  23. Pharmacokinetic disposition of benzimidazole drugs in the ruminant gastrointestinal tract. Hennessy, D.R. Parasitol. Today (Regul. Ed.) (1993) [Pubmed]
  24. Cross-resistance of nocodazole-resistant mutants of CHO cells toward other microtubule inhibitors: similar mode of action of benzimidazole carbamate derivatives and NSC 181928 and TN-16. Gupta, R.S. Mol. Pharmacol. (1986) [Pubmed]
  25. High resolution autoradiographical detection of RNA in the interchromatin granules of DRB-treated cells. Puvion, E., Viron, A., Xu, F.X. Exp. Cell Res. (1984) [Pubmed]
  26. A highly specific benzimidazole pyridazinone reverses phosphate-induced changes in cardiac myofilament activation. Westfall, M.V., Wahler, G.M., Solaro, R.J. Biochemistry (1993) [Pubmed]
  27. A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum. Cappello, M., Bungiro, R.D., Harrison, L.M., Bischof, L.J., Griffitts, J.S., Barrows, B.D., Aroian, R.V. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  28. A ligand-gated, hinged loop rearrangement opens a channel to a buried artificial protein cavity. Fitzgerald, M.M., Musah, R.A., McRee, D.E., Goodin, D.B. Nat. Struct. Biol. (1996) [Pubmed]
  29. Effect of albendazole on recurrent and residual alveolar echinococcosis of the liver after surgery. Ishizu, H., Uchino, J., Sato, N., Aoki, S., Suzuki, K., Kuribayashi, H. Hepatology (1997) [Pubmed]
  30. Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators. Schilling, S., Niestroj, A.J., Rahfeld, J.U., Hoffmann, T., Wermann, M., Zunkel, K., Wasternack, C., Demuth, H.U. J. Biol. Chem. (2003) [Pubmed]
  31. Binding of parbendazole to tubulin and its influence on microtubules in tissue-culture cells as revealed by immunofluorescence microscopy. Havercroft, J.C., Quinlan, R.A., Gull, K. J. Cell. Sci. (1981) [Pubmed]
  32. Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast. Gillett, E.S., Espelin, C.W., Sorger, P.K. J. Cell Biol. (2004) [Pubmed]
  33. Cell division cycle genes nda2 and nda3 of the fission yeast Schizosaccharomyces pombe control microtubular organization and sensitivity to anti-mitotic benzimidazole compounds. Umesono, K., Toda, T., Hayashi, S., Yanagida, M. J. Mol. Biol. (1983) [Pubmed]
  34. Insulin-like growth factor (IGF) I and retinoic acid induce the synthesis of IGF-binding protein 5 in rat osteoblastic cells. Dong, Y., Canalis, E. Endocrinology (1995) [Pubmed]
  35. Site-directed mutagenesis of Saccharomyces cerevisiae beta-tubulin: interaction between residue 167 and benzimidazole compounds. Li, J., Katiyar, S.K., Edlind, T.D. FEBS Lett. (1996) [Pubmed]
  36. Benzimidazole derivatives. 4. The recognition of the voluminous substituent attached to the basic amino group of 5-HT4 receptor antagonists. López-Rodríguez, M.L., Benhamú, B., Murcia, M., Alvaro, E., Campillo, M., Pardo, L. J. Comput. Aided Mol. Des. (2003) [Pubmed]
  37. Conformation of nucleosides: circular dichroism study on the syn-anti conformational equilibrium of 2-substituted benzimidazole nucleosides. Miles, D.W., Townsend, L.B., Miles, D.L., Eyring, H. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  38. Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase. Kukolj, G., McGibbon, G.A., McKercher, G., Marquis, M., Lefèbvre, S., Thauvette, L., Gauthier, J., Goulet, S., Poupart, M.A., Beaulieu, P.L. J. Biol. Chem. (2005) [Pubmed]
  39. Use of benzimidazole chemotherapy in human helminthiases: indications and efficacy. Cook, G.C. Parasitol. Today (Regul. Ed.) (1990) [Pubmed]
  40. In Vitro Metacestodicidal Activities of Genistein and Other Isoflavones against Echinococcus multilocularis and Echinococcus granulosus. Naguleswaran, A., Spicher, M., Vonlaufen, N., Ortega-Mora, L.M., Torgerson, P., Gottstein, B., Hemphill, A. Antimicrob. Agents Chemother. (2006) [Pubmed]
  41. Activities of benzimidazole D- and L-ribonucleosides in animal models of cytomegalovirus infections. Kern, E.R., Hartline, C.B., Rybak, R.J., Drach, J.C., Townsend, L.B., Biron, K.K., Bidanset, D.J. Antimicrob. Agents Chemother. (2004) [Pubmed]
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