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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Induction of intestinal tumors in rats by dextran sulfate sodium.

The carcinogenicity of dextran sulfate sodium was studied in inbred ACI rats. In group 1, 10 male rats were fed a 10% dextran sulfate sodium diet; in group 2, 14 male and 12 female rats were fed a 5% dextran sulfate sodium diet; and in the control group, 9 male and 9 female rats were given the basal diet without dextran sulfate sodium. After the start of the feeding regimen, all rats given the 10% dextran sulfate sodium diet died of severe diarrhea and anemia within 14 days and 15 of 23 surviving rats fed a 5% dextran sulfate sodium diet developed intestinal tumors between 134 and 215 days. These tumors were induced in the colon and cecum and consisted of adenomas, adenocarcinomas, and papillomas.[1]


  1. Induction of intestinal tumors in rats by dextran sulfate sodium. Hirono, I., Kuhara, K., Hosaka, S., Tomizawa, S., Golberg, L. J. Natl. Cancer Inst. (1981) [Pubmed]
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