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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosome.

The mammalian sex chromosomes are thought to be related to each other by sharing a common origin. That is, the X and Y chromosomes originally evolved from a pair of chromosomes that only differed at the locus determining sexual differentiation. For example, this evolutionary relationship is reflected during meiosis in chromosomal pairing between the tip of the human X chromosome short arm and the Y chromosome which presumably implies sequence homology. However, compelling genetic evidence for functional homology between the mammalian X and Y chromosome is lacking. We describe here the localization of a gene to the tip of the short arm of the human X chromosome and evidence for a related gene on the Y chromosome.[1]

References

  1. Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosome. Goodfellow, P., Banting, G., Sheer, D., Ropers, H.H., Caine, A., Ferguson-Smith, M.A., Povey, S., Voss, R. Nature (1983) [Pubmed]
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