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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Similar behavioural effects of 5-hydroxytryptamine and substance P injected intrathecally in mice.

Intrathecal injection of 5-hydroxytryptamine (5-HT) or of substance P in mice elicited a behavioural syndrome consisting of reciprocal hindlimb scratching and biting or licking, directed towards the caudal parts of the body. 5-Hydroxtryptamine elicited more scratching than did substance P, which in turn caused a greater number of biting or licking responses. The 5-HT- induced responses were mimicked by 5,6-dihydroxytryptamine and inhibited by the 5-HT receptor blocker metergoline. The present findings indicate that 5-HT, injected intrathecally, may have similar effects as substance P in stimulating sensory pathways in the spinal cord.[1]

References

  1. Similar behavioural effects of 5-hydroxytryptamine and substance P injected intrathecally in mice. Fasmer, O.B., Berge, O.G., Hole, K. Neuropharmacology (1983) [Pubmed]
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