Gene Review:
Htr4 - 5 hydroxytryptamine (serotonin) receptor 4
Mus musculus
Synonyms:
5-HT, 5-HT-4, 5-HT4, 5-hydroxytryptamine receptor 4, 5HTR4, ...
Hellweg,
Zueger,
Fink,
H??rtnagl,
Gass,
Pinna,
Costa,
Guidotti,
Compan,
Zhou,
Grailhe,
Gazzara,
Martin,
Gingrich,
Dumuis,
Brunner,
Bockaert,
Hen,
Nagase,
Ishii,
Shindou,
Ouchi,
Shimizu,
Paterson,
Thompson,
Belliveau,
Antalffy,
Trachtenberg,
Armstrong,
Kinney,
Andrews,
Ladenheim,
Epstein,
Cadet,
Murphy,
Green,
Mechan,
Elliott,
O'Shea,
Colado,
- Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice. Compan, V., Zhou, M., Grailhe, R., Gazzara, R.A., Martin, R., Gingrich, J., Dumuis, A., Brunner, D., Bockaert, J., Hen, R. J. Neurosci. (2004)
- Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors. Crabbe, J.C., Phillips, T.J., Feller, D.J., Hen, R., Wenger, C.D., Lessov, C.N., Schafer, G.L. Nat. Genet. (1996)
- A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors. Oksenberg, D., Marsters, S.A., O'Dowd, B.F., Jin, H., Havlik, S., Peroutka, S.J., Ashkenazi, A. Nature (1992)
- Reevaluation of reserpine-induced suppression of contact sensitivity. Evidence that reserpine interferes with T lymphocyte function independently of an effect on mast cells. Mekori, Y.A., Weitzman, G.L., Galli, S.J. J. Exp. Med. (1985)
- Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake. Pinna, G., Costa, E., Guidotti, A. Psychopharmacology (Berl.) (2006)
- Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice. Esaki, T., Cook, M., Shimoji, K., Murphy, D.L., Sokoloff, L., Holmes, A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Neural control of predatory aggression in wild and domesticated animals. Nikulina, E.M. Neuroscience and biobehavioral reviews. (1991)
- Serotonin transporter abnormality in the dorsal motor nucleus of the vagus in Rett syndrome: potential implications for clinical autonomic dysfunction. Paterson, D.S., Thompson, E.G., Belliveau, R.A., Antalffy, B.A., Trachtenberg, F.L., Armstrong, D.D., Kinney, H.C. J. Neuropathol. Exp. Neurol. (2005)
- Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Grimsby, J., Toth, M., Chen, K., Kumazawa, T., Klaidman, L., Adams, J.D., Karoum, F., Gal, J., Shih, J.C. Nat. Genet. (1997)
- Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change. Bartsch, D., Ghirardi, M., Skehel, P.A., Karl, K.A., Herder, S.P., Chen, M., Bailey, C.H., Kandel, E.R. Cell (1995)
- Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Burns, C.M., Chu, H., Rueter, S.M., Hutchinson, L.K., Canton, H., Sanders-Bush, E., Emeson, R.B. Nature (1997)
- The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). Green, A.R., Mechan, A.O., Elliott, J.M., O'Shea, E., Colado, M.I. Pharmacol. Rev. (2003)
- Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis. Calapai, G., Corica, F., Corsonello, A., Sautebin, L., Di Rosa, M., Campo, G.M., Buemi, M., Mauro, V.N., Caputi, A.P. J. Clin. Invest. (1999)
- No hypothermic response to serotonin in 5-HT7 receptor knockout mice. Hedlund, P.B., Danielson, P.E., Thomas, E.A., Slanina, K., Carson, M.J., Sutcliffe, J.G. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Transgenic mice with high levels of superoxide dismutase activity are protected from the neurotoxic effects of 2'-NH2-MPTP on serotonergic and noradrenergic nerve terminals. Andrews, A.M., Ladenheim, B., Epstein, C.J., Cadet, J.L., Murphy, D.L. Mol. Pharmacol. (1996)
- Airway hyperresponsiveness in transgenic mice overexpressing platelet activating factor receptor is mediated by an atropine-sensitive pathway. Nagase, T., Ishii, S., Shindou, H., Ouchi, Y., Shimizu, T. Am. J. Respir. Crit. Care Med. (2002)
- Characterization of homologous 5-hydroxytryptamine4 receptor desensitization in colliculi neurons. Ansanay, H., Sebben, M., Bockaert, J., Dumuis, A. Mol. Pharmacol. (1992)
- The 5-HT4 receptor: molecular cloning and pharmacological characterization of two splice variants. Gerald, C., Adham, N., Kao, H.T., Olsen, M.A., Laz, T.M., Schechter, L.E., Bard, J.A., Vaysse, P.J., Hartig, P.R., Branchek, T.A. EMBO J. (1995)
- Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Maricq, A.V., Peterson, A.S., Brake, A.J., Myers, R.M., Julius, D. Science (1991)
- Contribution of 5-HT2A receptor in nematode infection-induced murine intestinal smooth muscle hypercontractility. Zhao, A., Urban, J.F., Morimoto, M., Elfrey, J.E., Madden, K.B., Finkelman, F.D., Shea-Donohue, T. Gastroenterology (2006)
- New players in the 5-HT receptor field: genes and knockouts. Lucas, J.J., Hen, R. Trends Pharmacol. Sci. (1995)
- Olfactory bulbectomy in mice leads to increased BDNF levels and decreased serotonin turnover in depression-related brain areas. Hellweg, R., Zueger, M., Fink, K., H??rtnagl, H., Gass, P. Neurobiol. Dis. (2007)
- Expression and function of 5-HT4 receptors in the mouse enteric nervous system. Liu, M., Geddis, M.S., Wen, Y., Setlik, W., Gershon, M.D. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters. Zhu, C.B., Blakely, R.D., Hewlett, W.A. Neuropsychopharmacology (2006)
- T cell-dependent mast cell degranulation and release of serotonin in murine delayed-type hypersensitivity. Askenase, P.W., Bursztajn, S., Gershon, M.D., Gershon, R.K. J. Exp. Med. (1980)
- Pharmacological characterization of 5-hydroxytryptamine4(5-HT4) receptors positively coupled to adenylate cyclase in adult guinea pig hippocampal membranes: effect of substituted benzamide derivatives. Bockaert, J., Sebben, M., Dumuis, A. Mol. Pharmacol. (1990)
- 5-HT6 receptors positively coupled to adenylyl cyclase in striatal neurones in culture. Sebben, M., Ansanay, H., Bockaert, J., Dumuis, A. Neuroreport (1994)
- Regional gastric contractility alterations in a diabetic gastroparesis mouse model: effects of cholinergic and serotoninergic stimulation. James, A.N., Ryan, J.P., Crowell, M.D., Parkman, H.P. Am. J. Physiol. Gastrointest. Liver Physiol. (2004)
- 5-HT7 receptor is coupled to G alpha subunits of heterotrimeric G12-protein to regulate gene transcription and neuronal morphology. Kvachnina, E., Liu, G., Dityatev, A., Renner, U., Dumuis, A., Richter, D.W., Dityateva, G., Schachner, M., Voyno-Yasenetskaya, T.A., Ponimaskin, E.G. J. Neurosci. (2005)
- Effects of 5-HT receptor antagonists on seizure susceptibility and locomotor activity in DBA/2 mice. Semenova, T.P., Ticku, M.K. Brain Res. (1992)
- Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test. Yoshitake, T., Wang, F.H., Kuteeva, E., Holmberg, K., Yamaguchi, M., Crawley, J.N., Steiner, R., Bartfai, T., Ogren, S.O., Hökfelt, T., Kehr, J. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Serotonin 1B receptors in the developing somatosensory and visual cortices are located on thalamocortical axons. Bennett-Clarke, C.A., Leslie, M.J., Chiaia, N.L., Rhoades, R.W. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Increased anxiety of mice lacking the serotonin1A receptor. Parks, C.L., Robinson, P.S., Sibille, E., Shenk, T., Toth, M. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice. Travis, E.R., Wang, Y.M., Michael, D.J., Caron, M.G., Wightman, R.M. Proc. Natl. Acad. Sci. U.S.A. (2000)