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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Prosthetic replacement for the thoracic vena cava: an experimental study.

The superior vena cava (SVC) and thoracic inferior vena cava (IVC) were replaced in 46 dogs with autologous vein, knitted Dacron, glutaraldehyde-fixed porcine pericardium, unsupported polytetrafluorethylene (PTFE), and externally stented PTFE. After 30 days, patency rates were determined by contrast venography and were 100%, 9%, 50%, 75%, and 100%, respectively. The patency rates of Dacron and glutaraldehyde-fixed pericardium are considered unacceptable when compared to autologous vein (p less than 0.05). Stented PTFE exhibited a patency rate equal to that of autologous vein at 30 days, minimal graft reaction, excellent incorporation by host fibroblasts, and a smooth neointima. The external spiral support added to PTFE enchanced the thromboresistance of this graft in the thoracic venous system. Long-term follow-up is required to determine if the stented PTFE prosthesis remains comparable to autologous vein as a venous conduit.[1]


  1. Prosthetic replacement for the thoracic vena cava: an experimental study. Fiore, A.C., Brown, J.W., Cromartie, R.S., Ofstein, L.C., Peigh, P.S., Sears, N.S., Deschner, W.P., King, H. J. Thorac. Cardiovasc. Surg. (1982) [Pubmed]
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