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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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An extensive deletion causing overproduction of yeast iso-2-cytochrome c.

CYC7-H3 is a cis-dominant regulatory mutation that causes a 20-fold overproduction of yeast iso-2-cytochrome c. The CYC7-H3 mutation is an approximately 5 kb deletion with one breakpoint located in the 5' noncoding region of the CYC7 gene, approximately 200 base from the ATG initiation codon. The deletion apparently fuses a new regulatory region to the structural portion of the CYC7 locus. The CYC7-H3 deletion encompasses the RAD23 locus, which controls UV sensitivity and the ANP1 locus, which controls osmotic sensitivity. The gene cluster CYC7-RAD23-ANP1 displays striking similarity to the gene cluster CYC1-OSM1-RAD7, which controls, respectively, iso-1-cytochrome c, osmotic sensitivity and UV sensitivity. We suggest that these gene clusters are related by an ancient transpositional event.[1]

References

  1. An extensive deletion causing overproduction of yeast iso-2-cytochrome c. McKnight, G.L., Cardillo, T.S., Sherman, F. Cell (1981) [Pubmed]
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