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Gene Review

OSM1  -  Osm1p

Saccharomyces cerevisiae S288c

Synonyms: FRDS2, Fumarate reductase 2, J1659, NADH-dependent fumarate reductase, Osmotic sensitivity protein 1, ...
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High impact information on OSM1

  • Consistent with this, exposure of M. grisea appressoria to external hyperosmotic stress induced OSM1-dependent production of arabitol [1].
  • Most of the rearrangements were deletions of the three linked genes, CYC1, OSM1, and RAD7, and resulted from recombination involving the single Ty1 element and a solo delta in the same orientation [2].
  • Transposition of the gene cluster CYC1-OSM1-RAD7 in yeast [3].
  • One of the fumarate reductase isoenzymes from Saccharomyces cerevisiae is encoded by the OSM1 gene [4].
  • The deduced amino acid sequence of the OSM1 gene revealed that FRDS2 is synthesized as a precursor protein containing a presequence composed of 32 amino acid residues [4].

Associations of OSM1 with chemical compounds

  • A double mutant of the two fumarate reductase isozyme genes (OSM1 and FRDS) showed a succinate productivity of 50% as compared to the parent when cells were incubated in glucose-buffered solution [5].
  • Simultaneous disruption of the FRDS and OSM1 genes resulted in the inability of the yeasts to grow anaerobically on glucose as a carbon source, and disruption of the OSM1 gene caused poor growth under anaerobic conditions [6].
  • In the present study, we found that the anaerobic growth of the strain disrupted for both the FRDS and OSM1 genes was fully restored by adding the oxidized form of methylene blue or phenazine methosulfate, which non-enzymatically oxidize cellular NADH to NAD(+) [7].

Other interactions of OSM1

  • The spontaneous mutation cyc1-1 inactivates the CYC1 gene as well as the neighboring loci OSM1 and RAD7 [8].
  • Some of the deletions in the yeast Saccharomyces cerevisiae that encompass the CYC1 gene, which determines iso-1-cytochrome c, extend into the OSM1 gene, causing inhibition of growth on hypertonic media, and into the RAD7 gene, causing sensitivity to UV light [9].


  1. Independent signaling pathways regulate cellular turgor during hyperosmotic stress and appressorium-mediated plant infection by Magnaporthe grisea. Dixon, K.P., Xu, J.R., Smirnoff, N., Talbot, N.J. Plant Cell (1999) [Pubmed]
  2. Deletions extending from a single Ty1 element in Saccharomyces cerevisiae. Downs, K.M., Brennan, G., Liebman, S.W. Mol. Cell. Biol. (1985) [Pubmed]
  3. Transposition of the gene cluster CYC1-OSM1-RAD7 in yeast. Stiles, J.I., Friedman, L.R., Helms, C., Consaul, S., Sherman, F. J. Mol. Biol. (1981) [Pubmed]
  4. One of the fumarate reductase isoenzymes from Saccharomyces cerevisiae is encoded by the OSM1 gene. Muratsubaki, H., Enomoto, K. Arch. Biochem. Biophys. (1998) [Pubmed]
  5. Effect of gene disruptions of the TCA cycle on production of succinic acid in Saccharomyces cerevisiae. Arikawa, Y., Kuroyanagi, T., Shimosaka, M., Muratsubaki, H., Enomoto, K., Kodaira, R., Okazaki, M. J. Biosci. Bioeng. (1999) [Pubmed]
  6. Soluble fumarate reductase isoenzymes from Saccharomyces cerevisiae are required for anaerobic growth. Arikawa, Y., Enomoto, K., Muratsubaki, H., Okazaki, M. FEMS Microbiol. Lett. (1998) [Pubmed]
  7. Physiological role of soluble fumarate reductase in redox balancing during anaerobiosis in Saccharomyces cerevisiae. Enomoto, K., Arikawa, Y., Muratsubaki, H. FEMS Microbiol. Lett. (2002) [Pubmed]
  8. Physical analysis of the CYC1-sup4 interval in Saccharomyces cerevisiae. Shalit, P., Loughney, K., Olson, M.V., Hall, B.D. Mol. Cell. Biol. (1981) [Pubmed]
  9. Deletions of the iso-1-cytochrome c and adjacent genes of yeast: discovery of the OSM1 gene controlling osmotic sensitivity. Singh, A., Sherman, F. Genetics (1978) [Pubmed]
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