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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Phosphoproteins of chicken bone matrix. Proof of synthesis in bone tissue.

Twelve-day-old embryonic chick mandibles were cultured in vitro for 6 days. Measurements of the weights of the explants, their mineral and protein components, and the EDTA-extractable proteins established that bone tissue synthesizes O-phosphoserine- and O-phosphothreonine-containing phosphoproteins which are similar to those present in embryonic and postnatal chicken bone matrix. The synthesis of the phosphoproteins was further confirmed by the demonstration that radioactively labeled O-phosphoserine and O-phosphothreonine were identified in bone and in the EDTA-extractable phosphoproteins after pulse-labeling chick mandibles in vitro with radioactively labeled serine and threonine, respectively.[1]


  1. Phosphoproteins of chicken bone matrix. Proof of synthesis in bone tissue. Glimcher, M.J., Kossiva, D., Brickley-Parsons, D. J. Biol. Chem. (1984) [Pubmed]
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