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MeSH Review

Bone and Bones

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Disease relevance of Bone and Bones


High impact information on Bone and Bones

  • Vitamin D3-induced calcium binding protein in bone tissue [6].
  • The effects of intravenous pamidronate on the bone tissue of children and adolescents with osteogenesis imperfecta [7].
  • In addition, the degradative potential of osteoarthritic bone was considerably higher as demonstrated by increased matrix metalloproteinase 2 activity, and again the greater activity was associated with the subchondral bone tissue [8].
  • These observations support the premise that biologically active vitamin D metabolites stimulate bone tissue maturation, and that PTH is not required in this regard [9].
  • Insulin-like growth factor-binding protein-5 (IGFBP-5) is known to modulate the stimulatory effects of IGFs and is the major IGF-binding protein in bone tissue [10].

Chemical compound and disease context of Bone and Bones


Biological context of Bone and Bones


Anatomical context of Bone and Bones


Associations of Bone and Bones with chemical compounds


Gene context of Bone and Bones

  • TGF beta 1 is expressed predominantly in the mesodermal components of the embryo e.g. the hematopoietic cells of both fetal liver and the hemopoietic islands of the yolk sac, the mesenchymal tissues of several internal organs and in ossifying bone tissues [30].
  • These results suggest that TNF-alpha may contribute to the regulation of remodeling and inflammation of bone tissues through the JE gene product [31].
  • These data do not preclude the possibility that there was a production of cAMP within the bone tissue itself after PTH but suggest that there was no release of cAMP from the bone into the bone blood [32].
  • RANKL transcripts were expressed abundantly in the thymus and bone tissues of OVX rats. rRANKL has a single hydrophobic region between residues 53 and 69, which is most likely to serve as a transmembrane domain [33].
  • However, after 4 and 8 weeks, there was almost no change in BSP expression in any of the bone tissues [34].

Analytical, diagnostic and therapeutic context of Bone and Bones


  1. Osteoblasts express the inflammatory cytokine interleukin-6 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue. Marriott, I., Gray, D.L., Tranguch, S.L., Fowler, V.G., Stryjewski, M., Scott Levin, L., Hudson, M.C., Bost, K.L. Am. J. Pathol. (2004) [Pubmed]
  2. Expression and localization of estrogen receptor-beta in murine and human bone. Vidal, O., Kindblom, L.G., Ohlsson, C. J. Bone Miner. Res. (1999) [Pubmed]
  3. Expression of bone-related protein messenger RNA in human meningiomas: possible involvement of osteopontin in development of psammoma bodies. Hirota, S., Nakajima, Y., Yoshimine, T., Kohri, K., Nomura, S., Taneda, M., Hayakawa, T., Kitamura, Y. J. Neuropathol. Exp. Neurol. (1995) [Pubmed]
  4. Lipids isolated from bone induce the migration of human breast cancer cells. Silva, J., Dasgupta, S., Wang, G., Krishnamurthy, K., Ritter, E., Bieberich, E. J. Lipid Res. (2006) [Pubmed]
  5. CXCL12 chemokine up-regulates bone resorption and MMP-9 release by human osteoclasts: CXCL12 levels are increased in synovial and bone tissue of rheumatoid arthritis patients. Grassi, F., Cristino, S., Toneguzzi, S., Piacentini, A., Facchini, A., Lisignoli, G. J. Cell. Physiol. (2004) [Pubmed]
  6. Vitamin D3-induced calcium binding protein in bone tissue. Christakos, S., Norman, A.W. Science (1978) [Pubmed]
  7. The effects of intravenous pamidronate on the bone tissue of children and adolescents with osteogenesis imperfecta. Rauch, F., Travers, R., Plotkin, H., Glorieux, F.H. J. Clin. Invest. (2002) [Pubmed]
  8. Abnormal cancellous bone collagen metabolism in osteoarthritis. Mansell, J.P., Bailey, A.J. J. Clin. Invest. (1998) [Pubmed]
  9. 25-hydroxycholecalciferol-enhanced bone maturation in the parathyroprivic state. Russell, J.E., Avioli, L.V. J. Clin. Invest. (1975) [Pubmed]
  10. Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions. Kalus, W., Zweckstetter, M., Renner, C., Sanchez, Y., Georgescu, J., Grol, M., Demuth, D., Schumacher, R., Dony, C., Lang, K., Holak, T.A. EMBO J. (1998) [Pubmed]
  11. Effect of KCA-098 on the function of osteoblast-like cells and the formation of TRAP-positive multinucleated cells in a mouse bone marrow cell population. Kawashima, K., Inoue, T., Tsutsumi, N., Endo, H. Biochem. Pharmacol. (1996) [Pubmed]
  12. Plasma aluminium in a reference population: the effects of antacid consumption and its influence on biochemical indices of bone formation. Sharp, C.A., Perks, J., Worsfold, M., Day, J.P., Davie, M.W. Eur. J. Clin. Invest. (1993) [Pubmed]
  13. Moderately high consumption of ethanol suppresses bone resorption in ovariectomized but not in sexually intact adult female rats. Fanti, P., Monier-Faugere, M.C., Geng, Z., Cohen, D., Malluche, H.H. Alcohol. Clin. Exp. Res. (1997) [Pubmed]
  14. Interactions between ipriflavone and the estrogen receptor. Petilli, M., Fiorelli, G., Benvenuti, S., Frediani, U., Gori, F., Brandi, M.L. Calcif. Tissue Int. (1995) [Pubmed]
  15. A morphological study on obliteration of the temporal dorsal bullae using hydroxyapatite granules. Takahashi, S., Nakano, Y. The American journal of otology. (1996) [Pubmed]
  16. Osteoblasts are target cells for transformation in c-fos transgenic mice. Grigoriadis, A.E., Schellander, K., Wang, Z.Q., Wagner, E.F. J. Cell Biol. (1993) [Pubmed]
  17. Fluoride content in human iliac bone: results in controls, patients with fluorosis, and osteoporotic patients treated with fluoride. Boivin, G., Chapuy, M.C., Baud, C.A., Meunier, P.J. J. Bone Miner. Res. (1988) [Pubmed]
  18. Cellular localization of neprilysin in mouse bone tissue and putative role in hydrolysis of osteogenic peptides. Ruchon, A.F., Marcinkiewicz, M., Ellefsen, K., Basak, A., Aubin, J., Crine, P., Boileau, G. J. Bone Miner. Res. (2000) [Pubmed]
  19. Gene expression of retinoic acid receptors, retinoid-X receptors, and cellular retinol-binding protein I in bone and its regulation by vitamin A. Harada, H., Miki, R., Masushige, S., Kato, S. Endocrinology (1995) [Pubmed]
  20. Mitogenesis in fetal rat bone cells simultaneously exposed to type beta transforming growth factor and other growth regulators. Centrella, M., McCarthy, T.L., Canalis, E. FASEB J. (1987) [Pubmed]
  21. Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice. Kim, S.J., Uehara, H., Yazici, S., Langley, R.R., He, J., Tsan, R., Fan, D., Killion, J.J., Fidler, I.J. Cancer Res. (2004) [Pubmed]
  22. Phosphoproteins of chicken bone matrix. Proof of synthesis in bone tissue. Glimcher, M.J., Kossiva, D., Brickley-Parsons, D. J. Biol. Chem. (1984) [Pubmed]
  23. Macrophage colony-stimulating factor release and receptor expression in bone cells. Weir, E.C., Horowitz, M.C., Baron, R., Centrella, M., Kacinski, B.M., Insogna, K.L. J. Bone Miner. Res. (1993) [Pubmed]
  24. Thyroid hormones increase insulin-like growth factor I content in the medium of rat bone tissue. Lakatos, P., Caplice, M.D., Khanna, V., Stern, P.H. J. Bone Miner. Res. (1993) [Pubmed]
  25. A possible role of vitamin D in the genesis of parenteral-nutrition-induced metabolic bone disease. Shike, M., Sturtridge, W.C., Tam, C.S., Harrison, J.E., Jones, G., Murray, T.M., Husdan, H., Whitwell, J., Wilson, D.R., Jeejeebhoy, K.N. Ann. Intern. Med. (1981) [Pubmed]
  26. Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment. Lien, E.A., Solheim, E., Ueland, P.M. Cancer Res. (1991) [Pubmed]
  27. Prostaglandins and hypercalcemic states. Seyberth, H.W., Raisz, L.G., Oates, J.A. Annu. Rev. Med. (1978) [Pubmed]
  28. Increased expression of osteonectin and osteopontin, two bone matrix proteins, in human breast cancer. Bellahcène, A., Castronovo, V. Am. J. Pathol. (1995) [Pubmed]
  29. Characterization of fetal porcine bone sialoproteins, secreted phosphoprotein I (SPPI, osteopontin), bone sialoprotein, and a 23-kDa glycoprotein. Demonstration that the 23-kDa glycoprotein is derived from the carboxyl terminus of SPPI. Zhang, Q., Domenicucci, C., Goldberg, H.A., Wrana, J.L., Sodek, J. J. Biol. Chem. (1990) [Pubmed]
  30. Differential expression of TGF beta 1, beta 2 and beta 3 genes during mouse embryogenesis. Schmid, P., Cox, D., Bilbe, G., Maier, R., McMaster, G.K. Development (1991) [Pubmed]
  31. Tumor necrosis factor-alpha induces expression of monocyte chemoattractant JE via fos and jun genes in clonal osteoblastic MC3T3-E1 cells. Hanazawa, S., Takeshita, A., Amano, S., Semba, T., Nirazuka, T., Katoh, H., Kitano, S. J. Biol. Chem. (1993) [Pubmed]
  32. Skeletal contribution of cyclic adenosine monophosphate in response to parathyroid hormone and calcitonin in vivo in the rat. Morrison, N.E., Ramanathan, S., Suh, S.M. J. Bone Miner. Res. (1988) [Pubmed]
  33. Cloning, sequencing, and functional characterization of the rat homologue of receptor activator of NF-kappaB ligand. Xu, J., Tan, J.W., Huang, L., Gao, X.H., Laird, R., Liu, D., Wysocki, S., Zheng, M.H. J. Bone Miner. Res. (2000) [Pubmed]
  34. An in vivo model to study osteogenic gene regulation: targeting an avian retroviral receptor (TVA) to bone with the bone sialoprotein (BSP) promoter. Li, L., Zhu, J., Tu, Q., Yamauchi, M., Sodek, J., Karsenty, G., Tang, J., Chen, J. J. Bone Miner. Res. (2005) [Pubmed]
  35. Purification of matrix Gla protein from a marine teleost fish, Argyrosomus regius: calcified cartilage and not bone as the primary site of MGP accumulation in fish. Simes, D.C., Williamson, M.K., Ortiz-Delgado, J.B., Viegas, C.S., Price, P.A., Cancela, M.L. J. Bone Miner. Res. (2003) [Pubmed]
  36. Systemic administration of an anabolic dose of prostaglandin E2 induces early-response genes in rat bones. Weinreb, M., Rutledge, S.J., Rodan, G.A. Bone (1997) [Pubmed]
  37. Treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with a biodegradable system of lactic acid polymer releasing pefloxacin. Kanellakopoulou, K., Galanakis, N., Giamarellos-Bourboulis, E.J., Rifiotis, C., Papakostas, K., Andreopoulos, A., Dounis, E., Karagianakos, P., Giamarellou, H. J. Antimicrob. Chemother. (2000) [Pubmed]
  38. Macroporous calcium phosphate bioceramics in dog femora: a histological study of interface and biodegradation. Klein, C.P., Patka, P., den Hollander, W. Biomaterials (1989) [Pubmed]
  39. Effects of transforming growth factor beta1 on bonelike tissue formation in three-dimensional cell culture. II: Osteoblastic differentiation. Lieb, E., Vogel, T., Milz, S., Dauner, M., Schulz, M.B. Tissue engineering. (2004) [Pubmed]
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