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Chemical Compound Review

phosphoserine     (2S)-2-amino-3-phosphonooxy- propanoic acid

Synonyms: Fosforina, LSOP, Dexfosfoserine, L-SOP, Tocris-0238, ...
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Disease relevance of phosphoserine

  • The tissue content of L-phosphoserine was also sensitive to anoxia, falling almost fivefold within 5 min after the liver was removed [1].
  • CONCLUSIONS: After a total ischemia duration of 3 h there were signs of damage to the phospholipid membrane of the rat skeletal muscle, as demonstrated by the elevation of OPS and the few or no oxidative changes in the cell [2].

Psychiatry related information on phosphoserine


High impact information on phosphoserine


Chemical compound and disease context of phosphoserine


Biological context of phosphoserine


Anatomical context of phosphoserine


Associations of phosphoserine with other chemical compounds


Gene context of phosphoserine


Analytical, diagnostic and therapeutic context of phosphoserine


  1. The reactions of the phosphorylated pathway of L-serine biosynthesis: thermodynamic relationships in rabbit liver in vivo. Lund, K., Merrill, D.K., Guynn, R.W. Arch. Biochem. Biophys. (1985) [Pubmed]
  2. Indicators of oxidative injury and alterations of the cell membrane in the skeletal muscle of rats submitted to ischemia and reperfusion. Grisotto, P.C., dos Santos, A.C., Coutinho-Netto, J., Cherri, J., Piccinato, C.E. J. Surg. Res. (2000) [Pubmed]
  3. L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes. Klunk, W.E., McClure, R.J., Pettegrew, J.W. J. Neurochem. (1991) [Pubmed]
  4. Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors. Nicoletti, F., Iadarola, M.J., Wroblewski, J.T., Costa, E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  5. Cysteine biosynthesis in trichomonas vaginalis involves cysteine synthase utilizing O-phosphoserine. Westrop, G.D., Goodall, G., Mottram, J.C., Coombs, G.H. J. Biol. Chem. (2006) [Pubmed]
  6. The dynamic phosphorylation of the human intermediate filament keratin 1 chain. Steinert, P.M. J. Biol. Chem. (1988) [Pubmed]
  7. Phosphoproteins of chicken bone matrix. Proof of synthesis in bone tissue. Glimcher, M.J., Kossiva, D., Brickley-Parsons, D. J. Biol. Chem. (1984) [Pubmed]
  8. Phosphorus-31 nuclear magnetic resonance chemical shielding tensors of L-O-serine phosphate and 3'-cytidine monophosphate. Kohler, S.J., Klein, M.P. J. Am. Chem. Soc. (1977) [Pubmed]
  9. Protein p3 is linked to the DNA of phage phi 29 through a phosphoester bond between serine and 5'-dAMP. Hermoso, J.M., Salas, M. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  10. Pharmacokinetic study of the relative bioavailability and bioequivalence after oral intensive or repeated short term treatment with two polyamino acid formulations. Matera, M., Castana, R., Insirello, L., Leonardi, G. International journal of clinical pharmacology research. (1993) [Pubmed]
  11. O-phosphoserine content of intermediate filament subunits. Steinert, P.M., Wantz, M.L., Idler, W.W. Biochemistry (1982) [Pubmed]
  12. Entamoeba histolytica and Entamoeba dispar utilize externalized phosphatidylserine for recognition and phagocytosis of erythrocytes. Boettner, D.R., Huston, C.D., Sullivan, J.A., Petri, W.A. Infect. Immun. (2005) [Pubmed]
  13. Inhibition of cytosolic human forebrain choline acetyltransferase activity by phospho-L-serine: a phosphomonoester that accumulates during early stages of Alzheimer's disease. Andriamampandry, C., Kanfer, J.N. Neurobiol. Aging (1993) [Pubmed]
  14. Recent studies of the mineral phase in bone and its possible linkage to the organic matrix by protein-bound phosphate bonds. Glimcher, M.J. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1984) [Pubmed]
  15. Phosphorylation of a group of high molecular weight basic nuclear proteins during spermatogenesis in the winter flounder. Kennedy, B.P., Davies, P.L. J. Biol. Chem. (1981) [Pubmed]
  16. Crystal structure of phosphoserine aminotransferase from Escherichia coli at 2.3 A resolution: comparison of the unligated enzyme and a complex with alpha-methyl-l-glutamate. Hester, G., Stark, W., Moser, M., Kallen, J., Marković-Housley, Z., Jansonius, J.N. J. Mol. Biol. (1999) [Pubmed]
  17. Growth hormone promoted tyrosyl phosphorylation of growth hormone receptors in murine 3T3-F442A fibroblasts and adipocytes. Foster, C.M., Shafer, J.A., Rozsa, F.W., Wang, X.Y., Lewis, S.D., Renken, D.A., Natale, J.E., Schwartz, J., Carter-Su, C. Biochemistry (1988) [Pubmed]
  18. Comparison of excitatory amino acid-stimulated phosphoinositide hydrolysis and N-[3H]acetylaspartylglutamate binding in rat brain: selective inhibition of phosphoinositide hydrolysis by 2-amino-3-phosphonopropionate. Schoepp, D.D., Johnson, B.G. J. Neurochem. (1989) [Pubmed]
  19. Phosphopeptides and gamma-carboxyglutamic acid-containing peptides in calcified turkey tendon: their absence in uncalcified tendon. Glimcher, M.J., Brickley-Parsons, D., Kossiva, D. Calcif. Tissue Int. (1979) [Pubmed]
  20. Genetical and biochemical studies on human phosphoserine phosphatase. Moro-Furlani, A.M., Turner, V.S., Hopkinson, D.A. Ann. Hum. Genet. (1980) [Pubmed]
  21. Induction of rat L-phosphoserine phosphatase by amyloid-beta (1-42) is inhibited by interleukin-11. Heese, K., Nagai, Y., Sawada, T. Neurosci. Lett. (2000) [Pubmed]
  22. Abnormalities of phosphoprotein gene expression in three osteopetrotic rat mutations: elevated mRNA transcripts, protein synthesis, and accumulation in bone of mutant animals. Shalhoub, V., Bettencourt, B., Jackson, M.E., MacKay, C.A., Glimcher, M.J., Marks, S.C., Stein, G.S., Lian, J.B. J. Cell. Physiol. (1994) [Pubmed]
  23. Identification and quantitation of O-phosphoserine in human plasma fibronectin. Etheredge, R.E., Han, S., Fossel, E., Tanzer, M.L., Glimcher, M.J. FEBS Lett. (1985) [Pubmed]
  24. Changes in phosphoproteins of chicken bone matrix in vitamin D-deficient rickets. Lian, J.B., Cohen-Solal, L., Kossiva, D., Glimcher, M.J. FEBS Lett. (1982) [Pubmed]
  25. High-performance liquid chromatography of amino acids, peptides and proteins. CXXXI. O-phosphoserine as a new chelating ligand for use with hard Lewis metal ions in the immobilized-metal affinity chromatography of proteins. Zachariou, M., Traverso, I., Hearn, M.T. J. Chromatogr. (1993) [Pubmed]
  26. Purification and properties of phosphoserine aminotransferase from bovine liver. Lund, K., Merrill, D.K., Guynn, R.W. Arch. Biochem. Biophys. (1987) [Pubmed]
  27. The reactions of the phosphorylated pathway of L-serine biosynthesis: thermodynamic relationships in rat liver in vivo. Guynn, R.W., Merrill, D.K., Lund, K. Arch. Biochem. Biophys. (1986) [Pubmed]
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