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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Hyper IgE syndrome: four case report.

Patients with hyper IgE syndrome (HIES) have varying degree of immunological unbalance that account for deficiency of total T and OKT8 lymphocytes. To investigate the role of immunostimulating drugs in HIES, thymostimulin ( TP1) and levamisole were given in highly controlled groups of patients after a wash out period with disodium-chromoglycate (DSCG). Both drugs do not modify clinical picture whereas they do modulate some laboratory parameters as T lymphocyte total number, IgE plasmatic concentration, neutrophil chemotaxis. Furthermore TP1 had a worsening clinical effect in 3 of our patients. In our opinion we feel that the therapies proposed and employed so far for this rare disease must be critically analyzed.[1]

References

  1. Hyper IgE syndrome: four case report. Pigatto, P.D., Polenghi, M.M., Altomare, G.F., Brugo, A.M., Tadini, G.L., Morelli, M. Bollettino dell'Istituto sieroterapico milanese. (1984) [Pubmed]
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