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MeSH Review

Job's Syndrome

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Disease relevance of Job's Syndrome


High impact information on Job's Syndrome


Chemical compound and disease context of Job's Syndrome


Biological context of Job's Syndrome

  • Although decreased interferon-gamma (IFN-gamma) production in patients with hyper-IgE syndrome is pointed out and known as a cause of reduced neutrophil chemotaxis, precise mechanism of their inadequate production of IFN-gamma remains unknown [15].
  • In contrast, when blood from patients and controls was stimulated with heat-killed S. aureus or C. albicans, a severe imbalance towards a Th2 phenotype was found, with 10- to 30-fold reduction in the IFNgamma/IL-10 ratios in the hyper-IgE syndrome patients [16].

Anatomical context of Job's Syndrome


Gene context of Job's Syndrome


Analytical, diagnostic and therapeutic context of Job's Syndrome


  1. Circulating IgG autoantibodies to IgE in atopic syndromes. Quinti, I., Brozek, C., Wood, N., Geha, R.S., Leung, D.Y. J. Allergy Clin. Immunol. (1986) [Pubmed]
  2. 2. Update on primary immunodeficiency diseases. Bonilla, F.A., Geha, R.S. J. Allergy Clin. Immunol. (2006) [Pubmed]
  3. Recurrent colonic histoplasmosis after standard therapy with amphotericin B in a patient with Job's syndrome. Cappell, M.S., Manzione, N.C. Am. J. Gastroenterol. (1991) [Pubmed]
  4. Transfer factor therapy in hyperimmunoglobulinaemia E syndrome. Kesarwala, H.H., Prasad, R.V., Szep, R., Oldman, E., Lane, S., Papageorgiou, P.S. Clin. Exp. Immunol. (1979) [Pubmed]
  5. In vitro modulation of normal and diseased human neutrophil function by pentoxifylline. Boogaerts, M.A., Malbrain, S., Meeus, P., van Hove, L., Verhoef, G.E. Blut (1990) [Pubmed]
  6. The interleukin-4 receptor variant Q576R in hyper-IgE syndrome. Grimbacher, B., Holland, S.M., Puck, J.M. N. Engl. J. Med. (1998) [Pubmed]
  7. Levamisole in Job's syndrome. Swim, A.T., Bradac, C., Craddock, P.R. N. Engl. J. Med. (1982) [Pubmed]
  8. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. Hamid, Q., Azzawi, M., Ying, S., Moqbel, R., Wardlaw, A.J., Corrigan, C.J., Bradley, B., Durham, S.R., Collins, J.V., Jeffery, P.K. J. Clin. Invest. (1991) [Pubmed]
  9. Genetic linkage of hyper-IgE syndrome to chromosome 4. Grimbacher, B., Schäffer, A.A., Holland, S.M., Davis, J., Gallin, J.I., Malech, H.L., Atkinson, T.P., Belohradsky, B.H., Buckley, R.H., Cossu, F., Español, T., Garty, B.Z., Matamoros, N., Myers, L.A., Nelson, R.P., Ochs, H.D., Renner, E.D., Wellinghausen, N., Puck, J.M. Am. J. Hum. Genet. (1999) [Pubmed]
  10. Increased in vitro bone resorption by monocytes in the hyper-immunoglobulin E syndrome. Leung, D.Y., Key, L., Steinberg, J.J., Young, M.C., Von Deck, M., Wilkinson, R., Geha, R.S. J. Immunol. (1988) [Pubmed]
  11. Antibody responses to protein, polysaccharide, and phi X174 antigens in the hyperimmunoglobulinemia E (hyper-IgE) syndrome. Sheerin, K.A., Buckley, R.H. J. Allergy Clin. Immunol. (1991) [Pubmed]
  12. Cutaneous histamine levels and histamine releasability from the skin in atopic dermatitis and hyper-IgE-syndrome. Ruzicka, T., Glück, S. Arch. Dermatol. Res. (1983) [Pubmed]
  13. Demonstration of a cold abscess by gallium-67 imaging in a patient with Job syndrome. Jaramillo, D., Kim, E.E. AJR. American journal of roentgenology. (1986) [Pubmed]
  14. Lithium: a potential treatment for hyper-IgE syndrome. Namazi, M.R., Handjani, F. Med. Hypotheses (2006) [Pubmed]
  15. Selective insufficiency of IFN-gamma secretion in patients with hyper-IgE syndrome. Ito, R., Mori, M., Katakura, S., Kobayashi, N., Naruto, T., Osamura, Y., Aihara, Y., Yokota, S. Allergy (2003) [Pubmed]
  16. Th1/Th2 cytokine imbalance in a family with hyper-IgE syndrome. Netea, M.G., Schneeberger, P.M., de Vries, E., Kullberg, B.J., van der Meer, J.W., Koolen, M.I. The Netherlands journal of medicine. (2002) [Pubmed]
  17. Characterization of human T cell-derived IgE-potentiating factor. Young, M., Geha, R.S., Maksad, K.N., Leung, D.Y. Eur. J. Immunol. (1986) [Pubmed]
  18. Defective interleukin-12/interferon-gamma pathway in patients with hyperimmunoglobulinemia E syndrome. Borges, W.G., Augustine, N.H., Hill, H.R. J. Pediatr. (2000) [Pubmed]
  19. Use of recombinant human interferon gamma to enhance neutrophil chemotactic responses in Job syndrome of hyperimmunoglobulinemia E and recurrent infections. Jeppson, J.D., Jaffe, H.S., Hill, H.R. J. Pediatr. (1991) [Pubmed]
  20. Control of IgE responses. Durkin, H.G., Auci, D.L., Chice, S.M., Smith, M.C., Murali, M.R., Bazin, H., Tarcsay, L., Dukor, P. Clin. Immunol. Immunopathol. (1989) [Pubmed]
  21. Shifts in interleukin-4 and interferon-gamma production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis. Rousset, F., Robert, J., Andary, M., Bonnin, J.P., Souillet, G., Chrétien, I., Brière, F., Pène, J., de Vries, J.E. J. Allergy Clin. Immunol. (1991) [Pubmed]
  22. Increased expression of interleukin-13 but not interleukin-4 in CD4+ cells from patients with the hyper-IgE syndrome. Gudmundsson, K.O., Sigurjonsson, O.E., Gudmundsson, S., Goldblatt, D., Weemaes, C.M., Haraldsson, A. Clin. Exp. Immunol. (2002) [Pubmed]
  23. Abnormal expression of CD54 in mixed reactions of mononuclear cells from hyper-IgE syndrome patients. Martínez, A.M., Montoya, C.J., Rugeles, M.T., Franco, J.L., Patiño, P.J. Mem. Inst. Oswaldo Cruz (2004) [Pubmed]
  24. Selective deficiency of interferon-gamma production in the hyper-IgE syndrome. Relationship to in vitro IgE synthesis. Paganelli, R., Scala, E., Capobianchi, M.R., Fanales-Belasio, E., D'Offizi, G., Fiorilli, M., Aiuti, F. Clin. Exp. Immunol. (1991) [Pubmed]
  25. Cytokine and chemokine dysregulation in hyper-IgE syndrome. Chehimi, J., Elder, M., Greene, J., Noroski, L., Stiehm, E.R., Winkelstein, J.A., Sullivan, K.E. Clin. Immunol. (2001) [Pubmed]
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