Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Dahlström, U. et al.

Electrophysiological effects of prenalterol on the cardiac conduction system.

The electrophysiological effects of prenalterol, a new beta-receptor agonist, in a dose of 100 micrograms/kg body weight given intravenously for 5 min, were studied in 13 patients with signs of sinus node dysfunction and/or conduction defects within or distal to the atrioventricular (AV) node. In nine patients with signs of sinus node dysfunction a significant reduction was found in corrected sinus node recovery time, on an average by 1955 +/- 640 ms (-61%, P less than 0.05) and in atrial refractoriness, by 61 +/- 21 ms (-20%, P less than 0.05). Similar but insignificant changes were also seen in the four patients with normal sinus node function. In eight patients with AV nodal dysfunction, a significant increase was found in the Wenckebach point, by 51 +/- 10 b.p.m. (+52%. P less than 0.01) and a decrease in the AH interval, by 23 +/- 9 ms (-14%, P less than 0.05). AV nodal refractoriness tended to decrease by 115 +/- 58 ms (-24%, NS). Similar changes were found in the five patients with normal AV conduction. Heart rate increased in all 13 patients, on an average by 28 +/- 5 b.p.m. (+44%, P less than 0.001) and systolic blood pressure by 18 +/- 8 mmHg (+13% P less than 0.01). In conclusion, prenalterol increased sinus node automaticity and atrial and AV nodal conductivity, but did not improve infranodal conduction. Thus, the drug might be useful in the treatment of patients with sinus node dysfunction as well as in patients with spontaneous or induced atrioventricular conduction abnormalities.[1]

References

Electrophysiological effects of prenalterol on the cardiac conduction system. Dahlström, U., Lassvik, C. Eur. Heart J. (1983) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.