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Chemical Compound Review

AG-G-03027     4-[2-hydroxy-3-(propan-2...

Synonyms: SureCN10788435, AC1L4ARN, CTK8G2570, FT-0630699, L000886, ...
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Disease relevance of Prenalterol


Psychiatry related information on Prenalterol


High impact information on Prenalterol


Chemical compound and disease context of Prenalterol


Biological context of Prenalterol


Anatomical context of Prenalterol

  • Prenalterol, a beta-adrenergic agonist, was given to nine patients with angiographically proved coronary artery disease [17].
  • In conclusion, prenalterol increased sinus node automaticity and atrial and AV nodal conductivity, but did not improve infranodal conduction [4].
  • Prenalterol, an allegedly beta 1-selective adrenergic agonist with high intrinsic sympathomimetic activity (ISA), was shown to be weakly lipolytic in rat adipocytes [18].
  • To assess the role of the renal baroreceptor pathway to renin release after PNL, a suprarenal clamp was used to maintain a constant renal perfusion pressure during PNL infusion in a third group of dogs [19].
  • Effects of prenalterol on beta adrenergic responsiveness and receptors in the cerebral cortex of the rat [20].

Associations of Prenalterol with other chemical compounds


Gene context of Prenalterol


Analytical, diagnostic and therapeutic context of Prenalterol


  1. Long-term hemodynamic effects of prenalterol in patients with severe congestive heart failure. Lambertz, H., Meyer, J., Erbel, R. Circulation (1984) [Pubmed]
  2. Hemodynamic effects of prenalterol in patients with ischemic heart disease and congestive cardiomyopathy. Erbel, R., Meyer, J., Lambertz, H., Schweizer, P., Voelker, W., Krebs, W., Braun, G., Effert, S. Circulation (1982) [Pubmed]
  3. Intravenous and oral prenalterol in congestive heart failure. Effects on systemic and coronary hemodynamics and myocardial catecholamine balance. Wahr, D.W., Swedberg, K., Rabbino, M., Hoyle, M.J., Curran, D., Parmley, W.W., Chatterjee, K. Am. J. Med. (1984) [Pubmed]
  4. Electrophysiological effects of prenalterol on the cardiac conduction system. Dahlström, U., Lassvik, C. Eur. Heart J. (1983) [Pubmed]
  5. Influence of heart rate on the effects of prenalterol on regional myocardial blood flow and function during coronary stenosis in dogs. Berdeaux, A., Bonhenry, C., Duhazé, P., Giudicelli, J.F., Thuillez, C. Br. J. Pharmacol. (1984) [Pubmed]
  6. The role of beta- and alpha-adrenoceptors in the regulation of the stages of the sleep-waking cycle in the cat. Hilakivi, I. Brain Res. (1983) [Pubmed]
  7. Beta-adrenergic stimulation of the failing ventricle: a double-blind, randomized trial of sustained oral therapy with prenalterol. Roubin, G.S., Choong, C.Y., Devenish-Meares, S., Sadick, N.N., Fletcher, P.J., Kelly, D.T., Harris, P.J. Circulation (1984) [Pubmed]
  8. Hemodynamic, hormonal and electrolyte responses to prenalterol infusion in heart failure. Fitzpatrick, D., Ikram, H., Nicholls, M.G., Espiner, E.A. Circulation (1983) [Pubmed]
  9. Supersensitivity and changes in the active population of beta adrenoceptors in rat right atria in early sepsis. Barker, L.A., Winbery, S.L., Smith, L.W., McDonough, K.H. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  10. Inotropic effect of prenalterol in amitriptyline poisoning. Heath, A., Mårin, P., Sjöstrand, I. Intensive care medicine. (1984) [Pubmed]
  11. Effects of selective adrenergic agonists and antagonists on gastric tone in the rat. Bojö, L., Nellgård, P., Cassuto, J. Acta Physiol. Scand. (1991) [Pubmed]
  12. Severe atenolol and diltiazem overdose. Snook, C.P., Sigvaldason, K., Kristinsson, J. J. Toxicol. Clin. Toxicol. (2000) [Pubmed]
  13. Prenalterol in severe congestive heart failure. I. The immediate haemodynamic effects as compared to nitroglycerine. Tangø, M., Trap-Jensen, J., Rehling, M., Jespersen, C., Lyngborg, K. Danish medical bulletin. (1988) [Pubmed]
  14. Beta adrenergic influence on oesophageal peristalsis in man. Lyrenäs, E., Abrahamsson, H. Gut (1986) [Pubmed]
  15. Haemodynamic and cardiac metabolic effects of the new beta 1 agonist prenalterol in patients with cardiac failure. Kupper, W., Schütt, M., Hamm, C.W., Kuck, K.H., Hanrath, P., Bleifeld, W. Eur. Heart J. (1983) [Pubmed]
  16. Cardioselectivity of prenalterol and isoproterenol. Jennings, G., Bobik, A., Oddie, C., Hargreaves, M., Korner, P. Clin. Pharmacol. Ther. (1983) [Pubmed]
  17. Hemodynamic effects of atrial pacing and prenalterol infusion in patients taking beta-adrenergic blocking drugs. Shiu, M.F., Ireland, M.A., Littler, W.A. Circulation (1981) [Pubmed]
  18. The inhibitory GTP-binding protein (Gi) regulates the agonistic property of beta-adrenergic ligands in isolated rat adipocytes. Evidence for a priming effect of cyclic AMP. Wesslau, C., Smith, U. Biochem. J. (1992) [Pubmed]
  19. The systemic beta-adrenergic pathway to renin secretion: relationships with the renal prostaglandin system. Henrich, W.L., Campbell, W.B. Endocrinology (1983) [Pubmed]
  20. Effects of prenalterol on beta adrenergic responsiveness and receptors in the cerebral cortex of the rat. Ordway, G.A., Frazer, A. Neuropharmacology (1988) [Pubmed]
  21. Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium. Bristow, M.R., Hershberger, R.E., Port, J.D., Minobe, W., Rasmussen, R. Mol. Pharmacol. (1989) [Pubmed]
  22. Selectivity of xamoterol, prenalterol and salbutamol as assessed by their effects in the presence and absence of ICI 118 551. McCaffrey, P.M., Riddell, J.G., Shanks, R.G. Eur. Heart J. (1990) [Pubmed]
  23. Independent regulation of beta 1- and beta 2-adrenoceptors. Beer, M., Hacker, S., Poat, J., Stahl, S.M. Br. J. Pharmacol. (1987) [Pubmed]
  24. Beta adrenoceptor interaction of full and partial agonists in the cat heart and soleus muscle. Hedberg, A., Mattsson, H. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
  25. Effects of clenbuterol and prenalterol on behavior maintained under a multiple fixed-interval, fixed-ratio schedule. O'Donnell, J.M. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  26. Effect of selective beta-adrenoceptor stimulation on UCP synthesis in primary cultures of brown adipocytes. Puigserver, P., Picó, C., Stock, M.J., Palou, A. Mol. Cell. Endocrinol. (1996) [Pubmed]
  27. Effect of prenalterol in asthmatic patients. Löfdahl, C.G., Svedmyr, N. Eur. J. Clin. Pharmacol. (1982) [Pubmed]
  28. Studies on mechanisms for beta-adrenoceptor mediated inhibition of colon motility. Ek, B. Acta physiologica Scandinavica. Supplementum. (1985) [Pubmed]
  29. Prenalterol in primary dilated cardiomyopathy: hemodynamic and angiographic evaluation. Branzi, A., Specchia, S., Binetti, G., Magelli, C., Zannoli, R., Magnani, B. Eur. Heart J. (1983) [Pubmed]
  30. Sino-aortic denervation causes right atrial beta adrenoceptor down-regulation. Zanesco, A., Spadari-Bratfisch, R.C., Barker, L.A. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
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