The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Functional anatomy of L-5-hydroxytryptophan-induced myoclonus in the guinea pig.

Myoclonus was induced in guinea pigs in a dose-dependent manner by intraperitoneal injection of L-5-hydroxytryptophan (L-5-HTP). At a dosage of 400 mg per kilogram, all animals developed myoclonus. Autoradiographic analysis, using the [14C]-deoxyglucose method, showed increased glucose utilization in the ventral and ventral anterior thalamic nuclei and decreased glucose utilization in the cortex and molecular layer of the hippocampus. These changes were dose-dependent and occurred to a lesser extent in both myoclonic and non-myoclonic guinea pigs given an ED50 of L-5-HTP, demonstrating that the autoradiographic changes are not dependent on the presence of myoclonus. We believe that the thalamus is the final common pathway for the expression of myoclonus induced by L-5-HTP.[1]


WikiGenes - Universities