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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Pancreatic endocrine responses to exogenous neurotensin in the conscious calf.

1. Responses to neurotensin have been investigated in conscious calves 2-5 weeks after birth given continuous I.V. infusions of the peptide for 15 min (5 pmol. kg-1 . min-1). 2. In control calves the concentration of the peptide in the arterial plasma had risen by 160 +/- 10 pmol/l at the end of the infusion,. after which it fell exponentially (t1/2: 1.4 min). 3. This dose of neurotensin produced no significant change in mean heart rate, aortic blood pressure, plasma gastrin or glucose concentration. 4. It was found that neurotensin could produce a pronounced rise in the concentration of both insulin and pancreatic polypeptide ( PP) in the arterial plasma, together with a much smaller rise in pancreatic glucagon concentration. 5. Each of these three pancreatic endocrine responses was found to be glucose-sensitive within the range ca. 5.0-9.0 mmol/l. Hyperglycaemia potentiated insulin release and inhibited release of PP and glucagon. 6. The results are discussed in relation to the findings of other workers in other species.[1]


  1. Pancreatic endocrine responses to exogenous neurotensin in the conscious calf. Blackburn, A.M., Bloom, S.R., Edwards, A.V. J. Physiol. (Lond.) (1981) [Pubmed]
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