Biochemical diagnosis of vaginitis: determination of diamines in vaginal fluid.
To assess correlations between the content of the diamines putrescine and cadaverine in vaginal fluid and the clinical manifestations of vaginitis, a rapid procedure for the determination of diamines has been developed. The procedure involves thin-layer chromatography of the dansylated vaginal washings; then the fluorescence of dansyl diamines is compared with that of dansyl alanine. For 520 college women, the result of the test for diamines was positive in 173 (88%) of 197 women with nonspecific vaginitis or vaginitis due to Trichomonas vaginalis and was negative in 291 (90%) of 323 women without nonspecific vaginitis or vaginitis due to T. vaginalis. The diamine content of vaginal fluid specimens after therapy with metronidazole was correlated with the clinical response to treatment.[1]References
- Biochemical diagnosis of vaginitis: determination of diamines in vaginal fluid. Chen, K.C., Amsel, R., Eschenbach, D.A., Holmes, K.K. J. Infect. Dis. (1982) [Pubmed]
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