The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Trichomonas


High impact information on Trichomonas


Chemical compound and disease context of Trichomonas


Biological context of Trichomonas


Anatomical context of Trichomonas


Associations of Trichomonas with chemical compounds


Gene context of Trichomonas

  • The amitochondriate eukaryote Trichomonas vaginalis contains a divergent thioredoxin-linked peroxiredoxin antioxidant system [31].
  • Sequence data indicate that the thioredoxin reductase of Trichomonas differs fundamentally in structure from that of its human host and thus may represent a useful drug target [31].
  • Binding of fibronectin by Trichomonas vaginalis is influenced by iron and calcium [32].
  • Trichomonas vaginalis infection activates cells through toll-like receptor 4 [33].
  • Trichomonas vaginalis possesses a gene encoding the essential spliceosomal component, PRP8 [34].

Analytical, diagnostic and therapeutic context of Trichomonas


  1. Trifluoromethionine, a prodrug designed against methionine gamma-lyase-containing pathogens, has efficacy in vitro and in vivo against Trichomonas vaginalis. Coombs, G.H., Mottram, J.C. Antimicrob. Agents Chemother. (2001) [Pubmed]
  2. A pilot study of metronidazole vaginal gel versus oral metronidazole for the treatment of Trichomonas vaginalis vaginitis. duBouchet, L., McGregor, J.A., Ismail, M., McCormack, W.M. Sexually transmitted diseases. (1998) [Pubmed]
  3. Evaluation of use of a single intravaginal swab to detect multiple sexually transmitted infections in active-duty military women. Rompalo, A.M., Gaydos, C.A., Shah, N., Tennant, M., Crotchfelt, K.A., Madico, G., Quinn, T.C., Daniel, R., Shah, K.V., Gaydos, J.C., McKee, K.T. Clin. Infect. Dis. (2001) [Pubmed]
  4. Comparison of direct fluorescent antibody, acridine orange, wet mount, and culture for detection of Trichomonas vaginalis in women attending a public sexually transmitted diseases clinic. Bickley, L.S., Krisher, K.K., Punsalang, A., Trupei, M.A., Reichman, R.C., Menegus, M.A. Sexually transmitted diseases. (1989) [Pubmed]
  5. Cytotoxicity of hamycin for Trichomonas vaginalis, HeLa and BHK-21. Lushbaugh, W.B., Cleary, J.D., Finley, R.W. J. Antimicrob. Chemother. (1995) [Pubmed]
  6. Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection. Klebanoff, M.A., Carey, J.C., Hauth, J.C., Hillier, S.L., Nugent, R.P., Thom, E.A., Ernest, J.M., Heine, R.P., Wapner, R.J., Trout, W., Moawad, A., Leveno, K.J., Miodovnik, M., Sibai, B.M., Van Dorsten, J.P., Dombrowski, M.P., O'Sullivan, M.J., Varner, M., Langer, O., McNellis, D., Roberts, J.M. N. Engl. J. Med. (2001) [Pubmed]
  7. Transient myopia following metronidazole treatment for Trichomonas vaginalis. Grinbaum, A., Ashkenazi, I., Avni, I., Blumenthal, M. JAMA (1992) [Pubmed]
  8. Iron uptake and increased intracellular enzyme activity follow host lactoferrin binding by Trichomonas vaginalis receptors. Peterson, K.M., Alderete, J.F. J. Exp. Med. (1984) [Pubmed]
  9. The deoxyribonucleoside phosphotransferase of Trichomonas vaginalis. A potential target for anti-trichomonial chemotherapy. Wang, C.C., Cheng, H.W. J. Exp. Med. (1984) [Pubmed]
  10. New mechanisms of drug resistance in parasitic protozoa. Borst, P., Ouellette, M. Annu. Rev. Microbiol. (1995) [Pubmed]
  11. Inhibition of pyruvate:ferredoxin oxidoreductase from Trichomonas vaginalis by pyruvate and its analogues. Comparison with the pyruvate decarboxylase component of the pyruvate dehydrogenase complex. Williams, K.P., Leadlay, P.F., Lowe, P.N. Biochem. J. (1990) [Pubmed]
  12. Electrostatic effects in electron transfer reactions of [2Fe-2S] ferredoxins with inorganic reagents. Vidakovic, M., Germanas, J.P. Protein Sci. (1996) [Pubmed]
  13. Evaluation of a low-dose nonoxynol-9 gel for the prevention of sexually transmitted diseases: a randomized clinical trial. Richardson, B.A., Lavreys, L., Martin , H.L., Stevens, C.E., Ngugi, E., Mandaliya, K., Bwayo, J., Ndinya-Achola, J., Kreiss, J.K. Sexually transmitted diseases. (2001) [Pubmed]
  14. The preterm prediction study: significance of vaginal infections. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Meis, P.J., Goldenberg, R.L., Mercer, B., Moawad, A., Das, A., McNellis, D., Johnson, F., Iams, J.D., Thom, E., Andrews, W.W. Am. J. Obstet. Gynecol. (1995) [Pubmed]
  15. High expression, purification, and properties of recombinant homocysteine alpha, gamma-lyase. Han, Q., Lenz, M., Tan, Y., Xu, M., Sun, X., Tan, X., Tan, X., Tang, L., Miljkovic, D., Hoffman, R.M. Protein Expr. Purif. (1998) [Pubmed]
  16. Identification of Trichomonas vaginalis cysteine proteases that induce apoptosis in human vaginal epithelial cells. Sommer, U., Costello, C.E., Hayes, G.R., Beach, D.H., Gilbert, R.O., Lucas, J.J., Singh, B.N. J. Biol. Chem. (2005) [Pubmed]
  17. Molecular typing of Trichomonas vaginalis isolates by HSP70 restriction fragment length polymorphism. Stiles, J.K., Shah, P.H., Xue, L., Meade, J.C., Lushbaugh, W.B., Cleary, J.D., Finley, R.W. Am. J. Trop. Med. Hyg. (2000) [Pubmed]
  18. The contribution of the arginine dihydrolase pathway to energy metabolism by Trichomonas vaginalis. Yarlett, N., Martinez, M.P., Moharrami, M.A., Tachezy, J. Mol. Biochem. Parasitol. (1996) [Pubmed]
  19. Oxidative stress and Trichomonas vaginalis: the effect of hydrogen peroxide in vitro. Davis, S.R., Lushbaugh, W.B. Am. J. Trop. Med. Hyg. (1993) [Pubmed]
  20. Vaginal fetal fibronectin measurements from 8 to 22 weeks' gestation and subsequent spontaneous preterm birth. Goldenberg, R.L., Klebanoff, M., Carey, J.C., Macpherson, C., Leveno, K.J., Moawad, A.H., Sibai, B., Heine, R.P., Ernest, J.M., Dombrowski, M.P., Miodovnik, M., Wapner, R.J., Iams, J.D., Langer, O., O'sullivan, M.J., Roberts, J.M. Am. J. Obstet. Gynecol. (2000) [Pubmed]
  21. Production of interleukin-8 by human neutrophils stimulated with Trichomonas vaginalis. Ryu, J.S., Kang, J.H., Jung, S.Y., Shin, M.H., Kim, J.M., Park, H., Min, D.Y. Infect. Immun. (2004) [Pubmed]
  22. Generation of interleukin-8 from human monocytes in response to Trichomonas vaginalis stimulation. Shaio, M.F., Lin, P.R., Liu, J.Y., Yang, K.D. Infect. Immun. (1995) [Pubmed]
  23. HeLa cell nucleus, a source of thymidine for Trichomonas vaginalis growing in vitro. González-Lázaro, M., González-Robles, A., Hernández-Gutiérrez, R., Arroyo, R. Int. J. Biochem. Cell Biol. (2005) [Pubmed]
  24. Evaluation of acridine orange stain for detection of Trichomonas vaginalis in vaginal specimens. Greenwood, J.R., Kirk-Hillaire, K. J. Clin. Microbiol. (1981) [Pubmed]
  25. Molecular characterization of a sarcoplasmic-endoplasmic reticulum Ca+2 ATPase gene from Trichomonas vaginalis. Meade, J.C., Li, C., Moate, M.E., Davis-Hayman, S.R., Lushbaugh, W.B., Finley, R.W. J. Eukaryot. Microbiol. (1997) [Pubmed]
  26. Mitochondrial-type assembly of FeS centers in the hydrogenosomes of the amitochondriate eukaryote Trichomonas vaginalis. Sutak, R., Dolezal, P., Fiumera, H.L., Hrdy, I., Dancis, A., Delgadillo-Correa, M., Johnson, P.J., Müller, M., Tachezy, J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  27. Convergent evolution of Trichomonas vaginalis lactate dehydrogenase from malate dehydrogenase. Wu, G., Fiser, A., ter Kuile, B., Sali, A., Müller, M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  28. Treatment of infections caused by metronidazole-resistant Trichomonas vaginalis. Cudmore, S.L., Delgaty, K.L., Hayward-McClelland, S.F., Petrin, D.P., Garber, G.E. Clin. Microbiol. Rev. (2004) [Pubmed]
  29. The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5'-phosphate-dependent enzymes. McKie, A.E., Edlind, T., Walker, J., Mottram, J.C., Coombs, G.H. J. Biol. Chem. (1998) [Pubmed]
  30. Expression and spectroscopic characterization of the hydrogenosomal [2Fe-2S] ferredoxin from the protozoan Trichomonas vaginalis. Vidakovic, M.S., Fraczkiewicz, G., Germanas, J.P. J. Biol. Chem. (1996) [Pubmed]
  31. The amitochondriate eukaryote Trichomonas vaginalis contains a divergent thioredoxin-linked peroxiredoxin antioxidant system. Coombs, G.H., Westrop, G.D., Suchan, P., Puzova, G., Hirt, R.P., Embley, T.M., Mottram, J.C., Müller, S. J. Biol. Chem. (2004) [Pubmed]
  32. Binding of fibronectin by Trichomonas vaginalis is influenced by iron and calcium. Crouch, M.L., Benchimol, M., Alderete, J.F. Microb. Pathog. (2001) [Pubmed]
  33. Trichomonas vaginalis infection activates cells through toll-like receptor 4. Zariffard, M.R., Harwani, S., Novak, R.M., Graham, P.J., Ji, X., Spear, G.T. Clin. Immunol. (2004) [Pubmed]
  34. Trichomonas vaginalis possesses a gene encoding the essential spliceosomal component, PRP8. Fast, N.M., Doolittle, W.F. Mol. Biochem. Parasitol. (1999) [Pubmed]
  35. Analysis of the proteinases of representative Trichomonas vaginalis isolates. Neale, K.A., Alderete, J.F. Infect. Immun. (1990) [Pubmed]
  36. Heterogeneity of Trichomonas vaginalis and discrimination among trichomonal isolates and subpopulations with sera of patients and experimentally infected mice. Alderete, J.F., Suprun-Brown, L., Kasmala, L., Smith, J., Spence, M. Infect. Immun. (1985) [Pubmed]
  37. Treatment failure in Trichomonas vaginalis infections in females. I. Concentrations of metronidazole in plasma and vaginal content during normal and high dosage. Robertson, D.H., Heyworth, R., Harrison, C., Lumsden, W.H. J. Antimicrob. Chemother. (1988) [Pubmed]
  38. Molecular epidemiology of metronidazole resistance in a population of Trichomonas vaginalis clinical isolates. Snipes, L.J., Gamard, P.M., Narcisi, E.M., Beard, C.B., Lehmann, T., Secor, W.E. J. Clin. Microbiol. (2000) [Pubmed]
  39. Evaluation of the effects of albendazole and metronidazole on the ultrastructure of Giardia duodenalis, Trichomonas vaginalis and Spironucleus muris using transmission electron microscopy. Oxberry, M.E., Thompson, R.C., Reynoldson, J.A. Int. J. Parasitol. (1994) [Pubmed]
WikiGenes - Universities